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    Myl6 myosin light chain 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685867, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Myl6provided by RGD
    Official Full Name
    myosin light chain 6provided by RGD
    Primary source
    RGD:1589019
    See related
    Ensembl:ENSRNOG00000054140 AllianceGenome:RGD:1589019
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    LC17; MLC-3; Myl6l
    Summary
    Predicted to enable microfilament motor activity. Predicted to be a structural constituent of muscle. Predicted to be involved in muscle filament sliding and skeletal muscle tissue development. Predicted to be located in brush border. Predicted to be part of unconventional myosin complex. Orthologous to human MYL6 (myosin light chain 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 1707.2), Kidney (RPKM 1472.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1495301..1498512, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (910764..914062, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2906137..2909193, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene transfer RNA serine (anticodon CGA) 1 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 Neighboring gene uncharacterized LOC120093526 Neighboring gene myosin light chain 6B like 1 Neighboring gene extended synaptotagmin 1 Neighboring gene ribosomal protein S23, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genes up-regulated in hypertrophied ventricle. Iwai N, et al. Biochem Biophys Res Commun, 1995 Apr 17. PMID 7733921
    2. Preparation of monoclonal antibodies against human ventricular myosin light chain 1 (HVMLC1) for functional studies. Fu ZY, et al. Acta Biochim Biophys Sin (Shanghai), 2006 Sep. PMID 16953301
    3. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. Hailstones DL, et al. Mol Cell Biol, 1990 Mar. PMID 2304459, Free PMC Article
    4. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
    5. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC188345

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables microfilament motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microfilament motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of muscle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables structural constituent of muscle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in muscle contraction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in muscle filament sliding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in skeletal muscle tissue development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in brush border ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    part_of unconventional myosin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of unconventional myosin complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    myosin light polypeptide 6
    Names
    17 kDa myosin light chain
    myosin light chain 3
    myosin light chain A3
    myosin light chain alkali 3
    myosin, light chain 6, alkali, smooth muscle and non-muscle
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscle
    myosin, light polypeptide 6, alkali, smooth muscle and non-muscle-like
    non-muscle myosin alkali light chain
    smooth muscle and nonmuscle myosin light chain alkali 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109484.1 → NP_001102954.1  myosin light polypeptide 6

      See identical proteins and their annotated locations for NP_001102954.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474104
      UniProtKB/Swiss-Prot
      Q64119
      UniProtKB/TrEMBL
      A6KSD7
      Conserved Domains (1) summary
      PTZ00184
      Location:5 → 149
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1495301..1498512 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079906.2 → XP_038935834.1  myosin light polypeptide 6 isoform X3

      UniProtKB/Swiss-Prot
      Q64119
      Conserved Domains (1) summary
      PTZ00184
      Location:5 → 142
      PTZ00184; calmodulin; Provisional

    2. XM_063264265.1 → XP_063120335.1  myosin light polypeptide 6 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K6J5, A6KSE3

    3. XM_008765039.4 → XP_008763261.1  myosin light polypeptide 6 isoform X1

      See identical proteins and their annotated locations for XP_008763261.1

      UniProtKB/Swiss-Prot
      Q64119
      UniProtKB/TrEMBL
      B2GV99
      Related
      ENSRNOP00000080100.1
      Conserved Domains (1) summary
      PTZ00184
      Location:5 → 142
      PTZ00184; calmodulin; Provisional

    4. XM_017595113.3 → XP_017450602.1  myosin light polypeptide 6 isoform X5

      UniProtKB/TrEMBL
      A6KSD9
      Conserved Domains (1) summary
      PTZ00184
      Location:1 → 114
      PTZ00184; calmodulin; Provisional

    5. XM_063264268.1 → XP_063120338.1  myosin light polypeptide 6 isoform X6

      UniProtKB/TrEMBL
      A6KSE4

    6. XM_063264266.1 → XP_063120336.1  myosin light polypeptide 6 isoform X4

    7. XM_063264267.1 → XP_063120337.1  myosin light polypeptide 6 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q64119.3 GenPept UniProtKB/Swiss-Prot:Q64119

    Gene LinkOut

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    Chemical Information
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    Research Materials
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