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    Muc3 mucin 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687030, updated on 29-Feb-2024

    Summary

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    Official Symbol
    Muc3provided by RGD
    Official Full Name
    mucin 3provided by RGD
    Primary source
    RGD:3124
    See related
    AllianceGenome:RGD:3124
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Muc3a
    Summary
    Predicted to enable PDZ domain binding activity. Involved in response to hormone and response to vitamin A. Located in apical plasma membrane and cytoplasm. Used to study colitis. Biomarker of cholangitis; colitis; liver cirrhosis; and otitis media. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Muc3 in Genome Data Viewer
    Location:
    12q12
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (25139076..25175249)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (19527251..19536924)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (22535663..22584775)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene mucin-12-like Neighboring gene mucin-12-like Neighboring gene uncharacterized LOC120095911 Neighboring gene tripartite motif containing 56 Neighboring gene serpin family E member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats. Ito H, et al. J Nutr, 2009 Sep. PMID 19605529
    2. Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain. He Y, et al. Glycobiology, 2009 Oct. PMID 19561031
    3. Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3. Li Y, et al. Mol Cell Biochem, 2008 Jun. PMID 18401557
    4. Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3. Khatri IA, et al. Biochem J, 2004 Feb 15. PMID 14572308, Free PMC Article
    5. The carboxyl-terminal sequence of rat intestinal mucin RMuc3 contains a putative transmembrane region and two EGF-like motifs. Khatri IA, et al. Biochim Biophys Acta, 1997 May 22. PMID 9188795

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression of Muc3 gene was 3-fold higher in the colonic mucosa from high protein rats and 3.5-fold more expressed in the ileal mucosa from high protein rats than in normal protein rats.
      Title: High-protein diet differently modifies intestinal goblet cell characteristics and mucosal cytokine expression in ileum and colon.
    2. interaction of the heterodimer was independent of the N-glycans within the rodent Muc3 SEA module.
      Title: Role of N-glycosylation of the SEA module of rodent Muc3 in posttranslational processing of its carboxy-terminal domain.
    3. In rats fed the [high molecular weight konjac mannan] diet, ileal Muc2 gene expression was not affected, but that of Muc3 was lower than in those fed the control diet...
      Title: Soluble fiber viscosity affects both goblet cell number and small intestine mucin secretion in rats.
    4. The present study demonstrates how the conservative cleavage motif LS1KGS2IV1V2 contributes to posttranslational processing through mutagenesis of each residue in the LS(1)KGS2IV1V2 motif.
      Title: Contribution of the conservative cleavage motif to posttranslational processing of the carboxyl terminal domain of rodent Muc3.
    5. Identification of a proteolytic site sequence in the C-terminal domain of Mucin3.
      Title: Evidence for a second peptide cleavage in the C-terminal domain of rodent intestinal mucin Muc3.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to Gram-positive bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hormone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to vitamin A IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in apical plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in brush border membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in microvillus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mucin 3; uncharacterized protein Muc3
    Names
    Mucin3
    mucin 3, intestinal
    mucin 3A, cell surface associated
    mucin-12
    mucin-17

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      25139076..25175249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063271879.1 → XP_063127949.1  uncharacterized protein Muc3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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