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    Nemf nuclear export mediator factor [ Rattus norvegicus (Norway rat) ]

    Gene ID: 100322884, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Nemfprovided by RGD
    Official Full Name
    nuclear export mediator factorprovided by RGD
    Primary source
    RGD:2315525
    See related
    Ensembl:ENSRNOG00000056128 AllianceGenome:RGD:2315525
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sdccag1
    Summary
    Predicted to be involved in nuclear export. Predicted to be part of RQC complex. Orthologous to human NEMF (nuclear export mediator factor). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 149.6), Kidney (RPKM 148.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nemf in Genome Data Viewer
    Location:
    6q24
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (93527690..93571863, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (87791650..87835826, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (91611021..91676394, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene kelch domain containing 1 Neighboring gene DNA polymerase epsilon 2, accessory subunit Neighboring gene transcription factor BTF3-like Neighboring gene kelch domain containing 2 Neighboring gene microRNA mir-3084a-4 Neighboring gene uncharacterized LOC134479213 Neighboring gene ADP-ribosylation factor 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression pattern of mammalian cochlea outer hair cell (OHC) mRNA: screening of a rat OHC cDNA library. Harter C, et al. DNA Cell Biol, 1999 Jan. PMID 10025504
    2. A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing. Long SW, et al. Biosci Rep, 2011 Oct. PMID 21070191, Free PMC Article
    3. Drosophila caliban, a nuclear export mediator, can function as a tumor suppressor in human lung cancer cells. Bi X, et al. Oncogene, 2005 Dec 15. PMID 16103875
    4. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-aminoacyl-tRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosomal large subunit binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in CAT tailing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear export ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in rescue of stalled ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of RQC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosolic ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ribosome quality control complex subunit NEMF
    Names
    nuclear export mediator factor NEMF
    serologically defined colon cancer antigen 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170586.3 → NP_001164057.2  ribosome quality control complex subunit NEMF

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A2E1, A0A8I6ARH7
      Related
      ENSRNOP00000084632.1, ENSRNOT00000098306.1
      Conserved Domains (2) summary
      COG1293
      Location:1 → 642
      YloA; Predicted component of the ribosome quality control (RQC) complex, YloA/Tae2 family, contains fibronectin-binding (FbpA) and DUF814 domains [Translation, ribosomal structure and biogenesis]
      pfam11923
      Location:964 → 1055
      DUF3441; Domain of unknown function (DUF3441)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      93527690..93571863 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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