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    PNUTS Phosphatase 1 nuclear targeting subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33270, updated on 10-May-2024

    Summary

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    Official Symbol
    PNUTSprovided by FlyBase
    Official Full Name
    Phosphatase 1 nuclear targeting subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0053526
    Locus tag
    Dmel_CG33526
    See related
    AllianceGenome:FB:FBgn0053526
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG31657; CG33526; CG4124; Dmel\CG33526; pnuts; Pnuts; PNUTS-RB; PNUTSDm
    Summary
    Enables protein phosphatase 1 binding activity. Involved in developmental growth and gene expression. Predicted to be located in nucleus. Is expressed in several structures, including germ band; larval ventral nerve cord; and presumptive embryonic/larval system. Orthologous to human PPP1R10 (protein phosphatase 1 regulatory subunit 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PNUTS in Genome Data Viewer
    Location:
    21E2-21E2; 2-1.5 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (870465..877038)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (870465..877038)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene arouser Neighboring gene dribble Neighboring gene uncharacterized protein Neighboring gene neither inactivation nor afterpotential A Neighboring gene long non-coding RNA:CR45348

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing. Chan HY, et al. Mol Biol Cell, 2001 May. PMID 11359931, Free PMC Article
    2. A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons. Morton DJ, et al. PLoS Genet, 2020 Jul. PMID 32645003, Free PMC Article
    3. SR proteins control a complex network of RNA-processing events. Bradley T, et al. RNA, 2015 Jan. PMID 25414008, Free PMC Article
    4. PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth. Ciurciu A, et al. PLoS Genet, 2013 Oct. PMID 24204300, Free PMC Article
    5. A genetic screen for olfactory habituation mutations in Drosophila: analysis of novel foraging alleles and an underlying neural circuit. Eddison M, et al. PLoS One, 2012. PMID 23284741, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein phosphatase 1 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase 1 binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of PTW/PP1 phosphatase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase 1 nuclear targeting subunit
    Names
    CG33526-PA
    CG33526-PB
    CG33526-PD
    CG33526-PE
    PNUTS-PA
    PNUTS-PB
    PNUTS-PD
    PNUTS-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      870465..877038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014453.2 → NP_001014453.1  phosphatase 1 nuclear targeting subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014453.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70HU3, Q7KU01
      Conserved Domains (2) summary
      smart00356
      Location:1110 → 1130
      ZnF_C3H1; zinc finger
      pfam08711
      Location:92 → 142
      Med26; TFIIS helical bundle-like domain

    2. NM_001272921.1 → NP_001259850.1  phosphatase 1 nuclear targeting subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259850.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70HU3, Q7KU01
      Conserved Domains (2) summary
      smart00356
      Location:1110 → 1130
      ZnF_C3H1; zinc finger
      pfam08711
      Location:92 → 142
      Med26; TFIIS helical bundle-like domain

    3. NM_001014455.2 → NP_001014455.1  phosphatase 1 nuclear targeting subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014455.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70HU2, Q95R52, Q9VPU9
      Conserved Domains (1) summary
      PTZ00449
      Location:425 → 570
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

    4. NM_001014454.2 → NP_001014454.1  phosphatase 1 nuclear targeting subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014454.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q70HU2, Q95R52, Q9VPU9
      Conserved Domains (1) summary
      PTZ00449
      Location:425 → 570
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q70HU2 Q70HU2
    Q70HU3 Q70HU3
    Q7KU01 Q7KU01
    Q960J4 Q960J4
    Q9VPU9 Q9VPU9

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