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    zfh1 Zn finger homeodomain 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43650, updated on 10-May-2024

    Summary

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    Official Symbol
    zfh1provided by FlyBase
    Official Full Name
    Zn finger homeodomain 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0004606
    Locus tag
    Dmel_CG1322
    See related
    AllianceGenome:FB:FBgn0004606
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1322; Dmel\CG1322; l(3)00865; zfh-1; Zfh-1; ZFH-1; Zfh1; ZFh1; ZFH1; Zfh1a; zfl-1; zhf1
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon development; garland nephrocyte differentiation; and hemocyte development. Located in nucleus. Is expressed in several structures, including central nervous system; circulatory system; embryonic/larval nervous system; extended germ band embryo; and stage 5 embryo. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; Hirschsprung's disease; Mowat-Wilson syndrome; and posterior polymorphous corneal dystrophy 3. Orthologous to several human genes including ZEB1 (zinc finger E-box binding homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See zfh1 in Genome Data Viewer
    Location:
    100A4-100A5; 3-101 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30765926..30789202)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26591648..26614924)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR43238 Neighboring gene Niemann-Pick type C-2h Neighboring gene antisense RNA:CR45189 Neighboring gene mir-1013 stem loop Neighboring gene warts Neighboring gene dj-1beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A New Behavioral Test and Associated Genetic Tools Highlight the Function of Ventral Abdominal Muscles in Adult Drosophila. Pons M, et al. Front Cell Neurosci, 2017. PMID 29209177, Free PMC Article
    2. Transcription factor zfh1 downregulates Drosophila Imd pathway. Myllymäki H, et al. Dev Comp Immunol, 2013 Mar. PMID 23178405
    3. The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs. Fortini ME, et al. Mech Dev, 1991 Jun. PMID 1680376
    4. A new family of homeobox genes encoding multiple homeodomain and zinc finger motifs. Hashimoto T, et al. Mech Dev, 1992 Nov. PMID 1362648
    5. Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch. Antonello ZA, et al. EMBO J, 2015 Aug 4. PMID 26077448, Free PMC Article

    See all (340) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. mesodermal transcriptional network by genome-wide identification of Zinc finger homeodomain 1 (Zfh1) targets
      Title: Expanding the mesodermal transcriptional network by genome-wide identification of Zinc finger homeodomain 1 (Zfh1) targets.
    2. Zfh1 binds and downregulates salvador and kibra, two tumour suppressor genes of the Hippo/Wts/Yki pathway, thereby restricting Yki activation and proliferation to the Zfh1(+) stem cells.
      Title: Direct control of somatic stem cell proliferation factors by the Drosophila testis stem cell niche.
    3. Zfh1 levels are increased in somatic cells that contact germ cells, and Woc is required for a Stat92E-mediated upregulation of zfh1 transcription.
      Title: Without children is required for Stat-mediated zfh1 transcription and for germline stem cell differentiation.
    4. zfh1 is an important regulator of the immune response in Drosophila.
      Title: Transcription factor zfh1 downregulates Drosophila Imd pathway.
    5. Study shows a novel function for Zfh1 as an anti-apoptotic molecule and uncovers a cryptic JNK-dependent apoptotic programme in ePG10, which is normally blocked by Zfh1.
      Title: Zfh1 promotes survival of a peripheral glia subtype by antagonizing a Jun N-terminal kinase-dependent apoptotic pathway.
    6. Data show that cell fate decisions in the dorsal and lateral Twi- and Tin-positive mesoderm of Drosophila melanogaster depend on the antagonistic action of the transcription factor Lame duck and the zinc finger homeodomain factor Zfh1.
      Title: Antagonistic function of Lmd and Zfh1 fine tunes cell fate decisions in the Twi and Tin positive mesoderm of Drosophila melanogaster.
    7. Zfh-1 is a presumptive somatic target of Jak/STAT signaling, demonstrating that it is necessary and sufficient to maintain somatic stem cells.
      Title: Zfh-1 controls somatic stem cell self-renewal in the Drosophila testis and nonautonomously influences germline stem cell self-renewal.
    8. Study shows that Zfh1 cell autonomously regulates motoneuronal outgrowth and larval growth of neuromuscular junctions and that the growth of NMJs is dependent on the dosage of Zfh1.
      Title: The transcription factor Zfh1 is involved in the regulation of neuropeptide expression and growth of larval neuromuscular junctions in Drosophila melanogaster.
    9. Our observations on the regulation of Zfh-1 provide a new approach for examining the function of Zfh-1 in motor neurons and larval locomotion.
      Title: Differentiation of the Drosophila serotonergic lineage depends on the regulation of Zfh-1 by Notch and Eagle.
    10. Zfh1 is required for ventral motor axon exit from the CNS.
      Title: Zfh1, a somatic motor neuron transcription factor, regulates axon exit from the CNS.
    Submit: New GeneRIF Correction See all GeneRIFs (11)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in epithelial to mesenchymal transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in garland nephrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hemocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lymph gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mesoderm development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in mesoderm development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in muscle cell cellular homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Zn finger homeodomain 1
    Names
    CG1322-PA
    CG1322-PB
    CG1322-PE
    Zinc-finger homeodomain protein 1
    Zn homeodomain 1
    zfh1-PA
    zfh1-PB
    zfh1-PE
    zinc finger homeodomain 1
    zinc finger homeodomain protein-1
    zinc finger homeodomain-1
    zinc-finger homeobox gene
    zinc-finger homeodomain1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30765926..30789202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170522.4 → NP_733401.3  Zn finger homeodomain 1, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733401.3

      Status: REVIEWED

      Conserved Domains (5) summary
      COG5048
      Location:992 → 1045
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:969 → 989
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:703 → 755
      Homeobox; Homeobox domain
      pfam00096
      Location:355 → 377
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1009 → 1034
      zf-H2C2_2; Zinc-finger double domain

    2. NM_057502.5 → NP_476850.1  Zn finger homeodomain 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28166, Q59DT3, Q6NP51, Q8MSQ8, Q9VA39, Q9VA40
      Related
      FBpp0085063
      Conserved Domains (5) summary
      COG5048
      Location:992 → 1045
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:969 → 989
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:703 → 755
      Homeobox; Homeobox domain
      pfam00096
      Location:355 → 377
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:1009 → 1034
      zf-H2C2_2; Zinc-finger double domain

    3. NM_170523.3 → NP_733402.1  Zn finger homeodomain 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733402.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P28166
      Related
      FBpp0085064
      Conserved Domains (5) summary
      COG5048
      Location:685 → 738
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:662 → 682
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:396 → 448
      Homeobox; Homeobox domain
      pfam00096
      Location:48 → 70
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:702 → 727
      zf-H2C2_2; Zinc-finger double domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28166.2 P28166

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