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    CG4020 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31522, updated on 10-May-2024

    Summary

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    Official Symbol
    CG4020provided by FlyBase
    Primary source
    FLYBASE:FBgn0029821
    Locus tag
    Dmel_CG4020
    See related
    AllianceGenome:FB:FBgn0029821
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4020
    Summary
    Predicted to enable fatty-acyl-CoA reductase (alcohol-forming) activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult head and adult heart. Orthologous to human FAR1 (fatty acyl-CoA reductase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG4020 in Genome Data Viewer
    Location:
    5C7-5C7; 1-14 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5905746..5908001)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5799779..5802034)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45668 Neighboring gene uncharacterized protein Neighboring gene Actin 5C Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44108 Neighboring gene Serine hydroxymethyl transferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
    2. Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling. Ermanoska B, et al. Nat Commun, 2023 Mar 8. PMID 36890170, Free PMC Article
    3. Cadmium-induced genome-wide DNA methylation changes in growth and oxidative metabolism in Drosophila melanogaster. Guan DL, et al. BMC Genomics, 2019 May 9. PMID 31072326, Free PMC Article
    4. An inventory of peroxisomal proteins and pathways in Drosophila melanogaster. Faust JE, et al. Traffic, 2012 Oct. PMID 22758915, Free PMC Article
    5. Automated identification of putative methyltransferases from genomic open reading frames. Katz JE, et al. Mol Cell Proteomics, 2003 Aug. PMID 12872006

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4020-PA
    CG4020-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      5905746..5908001
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272335.1 → NP_001259264.1  uncharacterized protein Dmel_CG4020, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259264.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QU3, Q9W459
      Conserved Domains (2) summary
      cd09071
      Location:359 → 450
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:12 → 333
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs

    2. NM_132048.3 → NP_572276.1  uncharacterized protein Dmel_CG4020, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572276.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q29QU3, Q9W459
      Related
      FBpp0070789
      Conserved Domains (2) summary
      cd09071
      Location:359 → 450
      FAR_C; C-terminal domain of fatty acyl CoA reductases
      cd05236
      Location:12 → 333
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W459 Q9W459

    Gene LinkOut

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