U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Nep1 Neprilysin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31547, updated on 10-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Nep1provided by FlyBase
    Official Full Name
    Neprilysin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0029843
    Locus tag
    Dmel_CG5905
    See related
    AllianceGenome:FB:FBgn0029843
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5894; CG5905; CG5914; Dmel\CG5905; DmeNEP1; dNEP1; NEP; nep1; NEP1
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in adult head; embryonic/larval midgut; and epithelium. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to several human genes including MMEL1 (membrane metalloendopeptidase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Nep1 in Genome Data Viewer
    Location:
    5D4-5D5; 1-15 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6091205..6103971)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5985238..5998004)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44959 Neighboring gene uncharacterized protein Neighboring gene raptor Neighboring gene Multiple inositol polyphosphate phosphatase 2 Neighboring gene Ca[2+]-channel protein alpha[[1]] subunit T Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Drosophila Middle-Term Memory: Amnesiac is Required for PKA Activation in the Mushroom Bodies, a Function Modulated by Neprilysin 1. Turrel O, et al. J Neurosci, 2020 May 20. PMID 32303647, Free PMC Article
    2. Drosophila Neprilysin 1 Rescues Memory Deficits Caused by Amyloid-β Peptide. Turrel O, et al. J Neurosci, 2017 Oct 25. PMID 28931572, Free PMC Article
    3. Drosophila Neprilysins Are Involved in Middle-Term and Long-Term Memory. Turrel O, et al. J Neurosci, 2016 Sep 14. PMID 27629706, Free PMC Article
    4. The neprilysin (NEP) family of zinc metalloendopeptidases: genomics and function. Turner AJ, et al. Bioessays, 2001 Mar. PMID 11223883
    5. Toxicities of amyloid-beta and tau protein are reciprocally enhanced in the Drosophila model. Sun ZD, et al. Neural Regen Res, 2022 Oct. PMID 35259851, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    NOT involved_in protein processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in proteolysis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    neprilysin 1
    Names
    CG5905-PA
    CG5905-PB
    CG5905-PC
    CG5905-PD
    Nep1-PA
    Nep1-PB
    Nep1-PC
    Nep1-PD
    NP_001284925.1
    NP_001284926.1
    NP_511056.2
    NP_727065.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      6091205..6103971
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297997.1 → NP_001284926.1  neprilysin 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284926.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    2. NM_167059.2 → NP_727065.1  neprilysin 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727065.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Related
      FBpp0070837
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    3. NM_078501.3 → NP_511056.2  neprilysin 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511056.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Related
      FBpp0070838
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I

    4. NM_001297996.1 → NP_001284925.1  neprilysin 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284925.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W436
      Conserved Domains (1) summary
      cd08662
      Location:194 → 847
      M13; Peptidase family M13 includes neprilysin, endothelin-converting enzyme I
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W436.2 Q9W436

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous