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    gt giant [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31227, updated on 10-May-2024

    Summary

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    Official Symbol
    gtprovided by FlyBase
    Official Full Name
    giantprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001150
    Locus tag
    Dmel_CG7952
    See related
    AllianceGenome:FB:FBgn0001150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7952; Dm-gt; DM17; Dmel\CG7952; EG:BACH7M4.5; Giant; GIAN_DROME; Gt; GT; l(1)3Aa; l(1)giant
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including axon guidance; regionalization; and ring gland development. Located in nucleus. Is expressed in several structures, including ectoderm; ectoderm anlage; extended germ band embryo; head segment; and presumptive embryonic/larval nervous system. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    3A3-3A3; 1-1 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2427113..2428967, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2321146..2323000, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene technical knockout Neighboring gene brother of ihog Neighboring gene zeste

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polycomb-group recruitment to a Drosophila target gene is the default state that is inhibited by a transcriptional activator. Ghotbi E, et al. Sci Adv, 2021 Jul. PMID 34272248, Free PMC Article
    2. DNA-binding specificity of the PAR basic leucine zipper protein VBP partially overlaps those of the C/EBP and CREB/ATF families and is influenced by domains that flank the core basic region. Haas NB, et al. Mol Cell Biol, 1995 Apr. PMID 7891686, Free PMC Article
    3. Analysis of metamorphosis in Drosophila melanogaster: characterization of giant, an ecdysteroid-deficient mutant. Schwartz MB, et al. Dev Biol, 1984 May. PMID 6425099
    4. Region-specific defects in l(1)giant embryos of Drosophila melanogaster. Petschek JP, et al. Dev Biol, 1987 Jan. PMID 3098602
    5. Mitochondria as environments for the nuclear genome in Drosophila: mitonuclear G×G×E. Rand DM, et al. J Hered, 2022 Feb 17. PMID 34964900, Free PMC Article

    See all (476) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
      Title: Exploring a Drosophila Transcription Factor Interaction Network to Identify Cis-Regulatory Modules.
    2. there are two phases of transcriptional regulation for the gap gene giant in Drosophila
      Title: A quantitative validated model reveals two phases of transcriptional regulation for the gap gene giant in Drosophila.
    3. two polycomb response elements-containing regions at the Polycomb-group proteins target gene, giant, one at the promoter, and another approximately 6 kb upstream.
      Title: Mapping polycomb response elements at the Drosophilla melanogaster giant locus.
    4. Results showed Gt repression roles in the regulation of two groups of partially overlapping stripes and that Gt morphogen activity is part of the mechanism responsible for the differential positioning of these stripes borders.
      Title: Investigating giant (Gt) repression in the formation of partially overlapping pair-rule stripes.
    5. gt likely controls ecdysone production indirectly by contributing the peptidergic phenotype of the PTTH-producing neurons in the embryo
      Title: The Drosophila gap gene giant regulates ecdysone production through specification of the PTTH-producing neurons.
    6. The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt.
      Title: The Drosophila gap gene giant has an anterior segment identity function mediated through disconnected and teashirt.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in posterior head segmentation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell size IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ring gland development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland development TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in specification of segmental identity, labial segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zygotic determination of anterior/posterior axis, embryo NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in zygotic determination of anterior/posterior axis, embryo TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    giant
    Names
    CG7952-PB
    gt-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2427113..2428967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080310.3 → NP_525049.1  giant [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_525049.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9EQS3, P39572, Q7YU39, Q9V3N3
      Related
      FBpp0070444
      Conserved Domains (1) summary
      cd14695
      Location:383 → 440
      bZIP_HLF; Basic leucine zipper (bZIP) domain of Hepatic leukemia factor (HLF) and similar proteins: a DNA-binding and dimerization domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39572.2 P39572

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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