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    CG10029 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40883, updated on 10-May-2024

    Summary

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    Official Symbol
    CG10029provided by FlyBase
    Primary source
    FLYBASE:FBgn0037498
    Locus tag
    Dmel_CG10029
    See related
    AllianceGenome:FB:FBgn0037498
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG10029
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding. Predicted to be located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Is expressed in adult head. Orthologous to human ERP44 (endoplasmic reticulum protein 44). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG10029 in Genome Data Viewer
    Location:
    84D3-84D3; 3-48 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7315724..7317207, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (3141161..3142929, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44334 Neighboring gene long non-coding RNA:CR46130 Neighboring gene long non-coding RNA:CR46299 Neighboring gene long non-coding RNA:CR46224

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sir2 Acts through Hepatocyte Nuclear Factor 4 to maintain insulin Signaling and Metabolic Homeostasis in Drosophila. Palu RA, et al. PLoS Genet, 2016 Apr. PMID 27058248, Free PMC Article
    2. Comprehensive Identification and Alternative Splicing of Microexons in Drosophila. Pang TL, et al. Front Genet, 2021. PMID 33859668, Free PMC Article
    3. Cold acclimation wholly reorganizes the Drosophila melanogaster transcriptome and metabolome. MacMillan HA, et al. Sci Rep, 2016 Jun 30. PMID 27357258, Free PMC Article
    4. Transcriptomic analysis of inbreeding depression in cold-sensitive Drosophila melanogaster shows upregulation of the immune response. Vermeulen CJ, et al. J Evol Biol, 2013 Sep. PMID 23944235
    5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein folding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG10029-PA
    NP_649716.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7315724..7317207 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141459.2 → NP_649716.1  uncharacterized protein Dmel_CG10029 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649716.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VI96
      Related
      FBpp0081110
      Conserved Domains (4) summary
      cd02996
      Location:27 → 134
      PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by ...
      cd03070
      Location:142 → 237
      PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
      cd03072
      Location:248 → 357
      PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
      pfam13848
      Location:165 → 352
      Thioredoxin_6; Thioredoxin-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VI96 Q9VI96

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