cv-c crossveinless c [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: cv-cprovided by FlyBase
Official Full Name: crossveinless cprovided by FlyBase
Primary source: FLYBASE:FBgn0285955
Locus tag: Dmel_CG34389
See related: AllianceGenome:FB:FBgn0285955
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG14845; CG14846; CG14847; CG14848; CG14849; CG31319; CG31330; CG34389; CG8480; Cv-c; Dmel\CG34389; l(3)06951; rhoGAP88C; RhoGAP88C
Old locus tag: CG14846; CG14847; CG31319; CG31330; Dmel_CG14846; Dmel_CG14847; Dmel_CG31319; Dmel_CG31330
Summary: Enables GTPase activator activity. Involved in several processes, including cytoskeleton organization; embryonic morphogenesis; and open tracheal system development. Located in basolateral plasma membrane. Is expressed in several structures, including brain; imaginal disc; large field neurons; leg; and spermatozoon. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to several human genes including DLC1 (DLC1 Rho GTPase activating protein) and STARD13 (StAR related lipid transfer domain containing 13). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 88B8-88C2; 3-55 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (14391683..14481713, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (10217405..10307435, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sleep deprivation increases the excitability of dorsal fan-shaped body neurons, but this homeostatic adjustment is disrupted in short-sleeping crossveinless-c mutants
Title: Neuronal machinery of sleep homeostasis in Drosophila.
We present evidence that low level of beta-integrin accumulation at the basal side of PCV epithelial cells regulated by Cv-C provides an optimal extracellular environment for guiding BMP transport
Title: A feed-forward loop coupling extracellular BMP transport and morphogenesis in Drosophila wing.
Dystrophin and the Rho GTPase crossveinless-c signaling pathway likely interact at the postsynaptic side of the NMJ to maintain synaptic homeostasis.
Title: The RhoGAP crossveinless-c interacts with Dystrophin and is required for synaptic homeostasis at the Drosophila neuromuscular junction.
Crossveinless-c (Cv-c) function is required in tissues actively undergoing morphogenesis to regulate RhoGTPase activity to promote the coordinated organisation of the actin cytoskeleton.
Title: crossveinless-c is a RhoGAP required for actin reorganisation during morphogenesis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables GTPase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Rho protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in assembly of actomyosin apparatus involved in cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in head involution	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in imaginal disc-derived wing vein morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maintenance of epithelial integrity, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in metaphase/anaphase transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in midgut development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in sleep	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spiracle morphogenesis, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tracheal pit formation in open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: crossveinless c

Names: CG34389-PA; CG34389-PC; CG34389-PD; crossveinless-c; cv-c-PA; cv-c-PC; cv-c-PD; lethal (3) 06951

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

14391683..14481713 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001104318.2 → NP_001097788.1 crossveinless c, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097788.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR05, A8WHF8

Conserved Domains (3) summary

cd09538
Location:1382 → 1441

SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily

cd04375
Location:1893 → 2116

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cl14643
Location:2148 → 2343

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_001104316.2 → NP_001097786.1 crossveinless c, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001097786.1

Status: REVIEWED

UniProtKB/TrEMBL

A8JR05, A8WHF8

Conserved Domains (3) summary

cd09538
Location:1382 → 1441

SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily

cd04375
Location:1893 → 2116

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cl14643
Location:2148 → 2343

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
NM_169583.3 → NP_731907.1 crossveinless c, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731907.1

Status: REVIEWED

UniProtKB/TrEMBL

Q8SY28, Q9VFK2

Related

FBpp0111543

Conserved Domains (3) summary

cd09538
Location:48 → 107

SAM_DLC1,2-like; SAM domain of DLC1,2-like subfamily

cd04375
Location:559 → 782

RhoGAP_DLC1; RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a ...

cl14643
Location:814 → 1009

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily