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    cpa capping protein alpha [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37387, updated on 10-May-2024

    Summary

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    Official Symbol
    cpaprovided by FlyBase
    Official Full Name
    capping protein alphaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034577
    Locus tag
    Dmel_CG10540
    See related
    AllianceGenome:FB:FBgn0034577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cap1; CapZalpha; CG10540; Cp&abg;; Cpa; CpA; cpalpha; Dmel\CG10540; miro; scrd
    Summary
    Enables protein heterodimerization activity. Involved in several processes, including barbed-end actin filament capping; germarium-derived oocyte fate determination; and regulation of plasma membrane bounded cell projection assembly. Located in apical plasma membrane. Part of F-actin capping protein complex. Is active in Z disc. Colocalizes with adherens junction. Is expressed in adult head; adult heart; embryonic/larval midgut; and organism. Used to study developmental disorder of mental health. Orthologous to several human genes including CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See cpa in Genome Data Viewer
    Location:
    57B16-57B16; 2-92 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (21057787..21059883)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (16945292..16947388)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45148 Neighboring gene shotgun Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L54 Neighboring gene Chitinase 8 Neighboring gene Chitinase 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Variants in CAPZA2, a member of an F-actin capping complex, cause intellectual disability and developmental delay. Huang Y, et al. Hum Mol Genet, 2020 Jun 3. PMID 32338762, Free PMC Article
    2. Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels. Amândio AR, et al. PLoS One, 2014. PMID 24788460, Free PMC Article
    3. MicroRNA miR-7 Regulates Secretion of Insulin-Like Peptides. Agbu P, et al. Endocrinology, 2020 Feb 1. PMID 31875904, Free PMC Article
    4. Cofilin regulates axon growth and branching of Drosophila γ-neurons. Sudarsanam S, et al. J Cell Sci, 2020 Apr 28. PMID 32152181, Free PMC Article
    5. Homeostasis of the Drosophila adult retina by actin-capping protein and the Hippo pathway. Brás-Pereira C, et al. Commun Integr Biol, 2011 Sep. PMID 22046478, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that actin-capping protein subunits Cpa and Cpb stabilize each other's protein levels and can stimulate the production of each other's mRNA when the level of one of the subunit is reduced.
      Title: Subunits of the Drosophila actin-capping protein heterodimer regulate each other at multiple levels.
    2. Data show that the actin-Capping Protein (CP) alphabeta heterodimer, which regulates actin filament (F-actin) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK activation.
      Title: Drosophila actin-Capping Protein limits JNK activation by the Src proto-oncogene.
    3. findings show an interdependency between Hpo signaling activity and F-actin dynamics in which CP and Hpo pathway activities inhibit F-actin accumulation, and the reduction in F-actin in turn sustains Hpo pathway activity
      Title: Actin-Capping Protein and the Hippo pathway regulate F-actin and tissue growth in Drosophila.
    4. Enabled and Capping actin regulator proteins shape oogenesis.
      Title: Enabled and Capping protein play important roles in shaping cell behavior during Drosophila oogenesis.
    5. Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium
      Title: Actin capping protein alpha maintains vestigial-expressing cells within the Drosophila wing disc epithelium.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of F-actin capping protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    capping protein alpha
    Names
    CG10540-PA
    actin capping protein
    actin-capping protein
    capping alpha
    capping protein
    capping protein A
    capping proteinalpha
    cpa-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      21057787..21059883
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137695.4 → NP_611539.1  capping protein alpha [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611539.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9W2N0
      Related
      FBpp0071461
      Conserved Domains (1) summary
      pfam01267
      Location:15 → 284
      F-actin_cap_A; F-actin capping protein alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W2N0.1 Q9W2N0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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