GluRIIC Glutamate receptor IIC [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: GluRIICprovided by FlyBase
Official Full Name: Glutamate receptor IICprovided by FlyBase
Primary source: FLYBASE:FBgn0046113
Locus tag: Dmel_CG4226
See related: AllianceGenome:FB:FBgn0046113
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG4226; CT13021; DGluR-IIC; DGluRIIC; DGluRIII; DmelGluRIIC; Dmel\CG4226; GluR; GluR3; GluRC; GluRII-C; GluRIIc; GLURIIC; GluRIIC/III; GluRIII; GLURIII; glutamate receptor III; GlutRIII
Summary: Enables glutamate-gated calcium ion channel activity. Involved in calcium ion transport; establishment of protein localization; and neuromuscular synaptic transmission. Located in muscle cell postsynaptic specialization. Part of ionotropic glutamate receptor complex. Is expressed in several structures, including embryonic/larval neuromuscular junction; foregut primordium; hindgut proper primordium; muscle cell; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Huntington's disease; autosomal recessive non-syndromic intellectual disability; autosomal recessive spinocerebellar ataxia 18; and childhood absence epilepsy. Orthologous to several human genes including GRID1 (glutamate ionotropic receptor delta type subunit 1); GRID2 (glutamate ionotropic receptor delta type subunit 2); and GRIK1 (glutamate ionotropic receptor kainate type subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 21E2-21E2; 2-1.5 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (914086..917805)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (914086..917805)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DGluRIII is a third glutamate receptor subunit at the Drosophila neuromuscular junction required for viability and the synaptic localization of DGluRIIA and DGluRIIB and synaptic transmission.
Title: Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables glutamate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate receptor activity	NAS Non-traceable Author Statement more info	PubMed
enables glutamate-gated calcium ion channel activity	IDA Inferred from Direct Assay more info	PubMed
enables glutamate-gated receptor activity	IC Inferred by Curator more info	PubMed
enables kainate selective glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables ligand-gated monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in neuromuscular synaptic transmission	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic transmission, glutamatergic	IBA Inferred from Biological aspect of Ancestor more info
involved_in synaptic transmission, glutamatergic	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of ionotropic glutamate receptor complex	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in muscle cell postsynaptic specialization	IDA Inferred from Direct Assay more info	PubMed
located_in neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: glutamate receptor IIC

Names: CG4226-PD; GluRIIC-PD; common type III glutamate receptor subunit; essential glutamate receptor subunit III; glutamate receptor; glutamate receptor III; glutamate receptor subunit III

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

914086..917805

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_134713.4 → NP_608557.4 glutamate receptor IIC [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_608557.4

Status: REVIEWED

UniProtKB/TrEMBL

B3DMP9, Q9VPV3

Conserved Domains (4) summary

cd06382
Location:26 → 404

PBP1_iGluR_Kainate; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the kainate receptors

cd13714
Location:423 → 794

PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily

pfam00060
Location:554 → 828

Lig_chan; Ligand-gated ion channel

cl10011
Location:279 → 363

Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily