spict spichthyin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: spictprovided by FlyBase
Official Full Name: spichthyinprovided by FlyBase
Primary source: FLYBASE:FBgn0032451
Locus tag: Dmel_CG12292
See related: AllianceGenome:FB:FBgn0032451
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG12292; Dmel\CG12292; spg6; Spict
Summary: Predicted to enable magnesium ion transmembrane transporter activity. Involved in negative regulation of BMP signaling pathway; negative regulation of synaptic assembly at neuromuscular junction; and positive regulation of axon extension involved in regeneration. Predicted to be integral component of membrane. Predicted to be active in membrane. Is expressed in several structures, including embryonic somatic muscle cell; embryonic/larval central nervous system; embryonic/larval circulatory system; presumptive embryonic/larval digestive system; and wing disc. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 6 and hereditary spastic paraplegia 6. Orthologous to several human genes including NIPAL1 (NIPA like domain containing 1); NIPAL4 (NIPA like domain containing 4); and NIPA2 (NIPA magnesium transporter 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 33F3-33F3; 2-47 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (12704725..12706683)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (12704725..12706683)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study shows that spict is upregulated in cyst cells that phagocytose dying spermatogonia. Study proposes that phagocytosis and subsequent clearance of dead spermatogonia, which is partly promoted by Spict, contribute to stem cell maintenance during prolonged protein starvation.
Title: spict, a cyst cell-specific gene, regulates starvation-induced spermatogonial cell death in the Drosophila testis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables magnesium ion transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in magnesium ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in magnesium ion transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of synaptic assembly at neuromuscular junction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of axon extension involved in regeneration	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: spichthyin

Names: CG12292-PA; CG12292-PB; spict-PA; spict-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

12704725..12706683

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_135742.4 → NP_609586.1 spichthyin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609586.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VK62

Related

FBpp0079978

Conserved Domains (1) summary

pfam05653
Location:43 → 338

Mg_trans_NIPA; Magnesium transporter NIPA
NM_001273492.1 → NP_001260421.1 spichthyin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260421.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PD12

Conserved Domains (1) summary

pfam05653
Location:43 → 338

Mg_trans_NIPA; Magnesium transporter NIPA