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    U2af38 U2 small nuclear riboprotein auxiliary factor 38 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33201, updated on 10-May-2024

    Summary

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    Official Symbol
    U2af38provided by FlyBase
    Official Full Name
    U2 small nuclear riboprotein auxiliary factor 38provided by FlyBase
    Primary source
    FLYBASE:FBgn0017457
    Locus tag
    Dmel_CG3582
    See related
    AllianceGenome:FB:FBgn0017457
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3582; Dmel\CG3582; dU2AF38; DU2AF38; dU2AF[38]; l(2)06751; U2AF; U2AF 38; u2af38; U2AF38; Utaf38
    Summary
    Enables poly-pyrimidine tract binding activity. Involved in mRNA splicing, via spliceosome and regulation of alternative mRNA splicing, via spliceosome. Part of U2AF complex. Is expressed in embryonic brain; embryonic/larval brain; gonad; imaginal disc; and organism. Orthologous to human U2AF1 (U2 small nuclear RNA auxiliary factor 1) and U2AF1L4 (U2 small nuclear RNA auxiliary factor 1 like 4). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See U2af38 in Genome Data Viewer
    Location:
    21B7-21B8; 2-0.5 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (292959..294681, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (292959..294681, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46262 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR46263 Neighboring gene amnionless Neighboring gene uncharacterized protein Neighboring gene Stress induced phosphoprotein 1 Neighboring gene Pi3K21B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RNA binding activity of heterodimeric splicing factor U2AF: at least one RS domain is required for high-affinity binding. Rudner DZ, et al. Mol Cell Biol, 1998 Jul. PMID 9632785, Free PMC Article
    2. Molecular genetic analysis of the heterodimeric splicing factor U2AF: the RS domain on either the large or small Drosophila subunit is dispensable in vivo. Rudner DZ, et al. Genes Dev, 1998 Apr 1. PMID 9531538, Free PMC Article
    3. The control of lipid metabolism by mRNA splicing in Drosophila. Gingras RM, et al. Biochem Biophys Res Commun, 2014 Jan 10. PMID 24333419, Free PMC Article
    4. Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping. Nagengast AA, et al. Development, 2003 Feb. PMID 12490553
    5. Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. Rudner DZ, et al. Mol Cell Biol, 1998 Apr. PMID 9528748, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables poly-pyrimidine tract binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pre-mRNA 3'-splice site binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
    involved_in regulation of alternative mRNA splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2AF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2AF complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2AF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    part_of precatalytic spliceosome HDA PubMed 
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    U2 small nuclear riboprotein auxiliary factor 38
    Names
    CG3582-PA
    CG3582-PB
    U2af38-PA
    U2af38-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      292959..294681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272885.1 → NP_001259814.1  U2 small nuclear riboprotein auxiliary factor 38, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259814.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94535, Q9VPN4
      UniProtKB/TrEMBL
      M9PBM1
      Conserved Domains (2) summary
      cd12538
      Location:43 → 148
      RRM_U2AF35; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)
      pfam00642
      Location:13 → 39
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    2. NM_057860.4 → NP_477208.1  U2 small nuclear riboprotein auxiliary factor 38, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477208.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94535, Q9VPN4
      UniProtKB/TrEMBL
      M9PBM1
      Related
      FBpp0077792
      Conserved Domains (2) summary
      cd12538
      Location:43 → 148
      RRM_U2AF35; RNA recognition motif in U2 small nuclear ribonucleoprotein auxiliary factor U2AF 35 kDa subunit (U2AF35)
      pfam00642
      Location:13 → 39
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PBM1 M9PBM1
    Q94535.2 Q94535

    Gene LinkOut

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