U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Glys Glycogen synthase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41823, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Glysprovided by FlyBase
    Official Full Name
    Glycogen synthaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266064
    Locus tag
    Dmel_CG6904
    See related
    AllianceGenome:FB:FBgn0266064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.108; CG6904; CG6940; dGS; Dmel\CG6904; GlyS; GS; Gys
    Summary
    Enables glycogen (starch) synthase activity. Involved in several processes, including cellular response to sucrose stimulus; glycogen metabolic process; and positive regulation of glycogen catabolic process. Located in cytoplasm. Is expressed in several structures, including anterior endoderm anlage; embryonic/larval muscle system; extended germ band embryo; foregut primordium; and gastrula embryo. Used to study Lafora disease. Human ortholog(s) of this gene implicated in cardiovascular system disease and glycogen storage disease. Orthologous to human GYS1 (glycogen synthase 1) and GYS2 (glycogen synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    88E2-88E2; 3-56 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15141843..15147531, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (10967565..10973253, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45600 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Guanylyl cyclase at 88E Neighboring gene Myofilin Neighboring gene mir-3644 stem loop Neighboring gene Kip1 ubiquitination-promoting complex subunit 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Alterations in brain glycogen levels influence life-history traits and reduce the lifespan in female Drosophila melanogaster. Sheshadri D, et al. Biol Open, 2021 Dec 15. PMID 34817590, Free PMC Article
    2. Neuronal glycogen synthesis contributes to physiological aging. Sinadinos C, et al. Aging Cell, 2014 Oct. PMID 25059425, Free PMC Article
    3. The role of glycogen in development and adult fitness in Drosophila. Yamada T, et al. Development, 2019 Apr 15. PMID 30918052
    4. Trehalose metabolism confers developmental robustness and stability in Drosophila by regulating glucose homeostasis. Matsushita R, et al. Commun Biol, 2020 Apr 7. PMID 32265497, Free PMC Article
    5. Feedforward Regulation of Glucose Metabolism by Steroid Hormones Drives a Developmental Transition in Drosophila. Nishimura T. Curr Biol, 2020 Sep 21. PMID 32679096

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glycogen (starch) synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycogen (starch) synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glycogen (starch) synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to sucrose stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glycogen biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glycogen catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to sucrose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    glycogen synthase
    Names
    CG6904-PA
    CG6904-PB
    CG6904-PC
    CG6904-PD
    Glys-PA
    Glys-PB
    Glys-PC
    Glys-PD
    NP_001262583.1
    NP_650422.1
    NP_731967.2
    NP_731968.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15141843..15147531 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169611.2 → NP_731968.1  glycogen synthase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731968.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Related
      FBpp0082494
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase

    2. NM_142165.3 → NP_650422.1  glycogen synthase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Related
      FBpp0082495
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase

    3. NM_001275654.1 → NP_001262583.1  glycogen synthase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262583.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ5
      Conserved Domains (1) summary
      pfam05693
      Location:33 → 677
      Glycogen_syn; Glycogen synthase

    4. NM_169610.2 → NP_731967.2  glycogen synthase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731967.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V2X5, Q9VFC8
      UniProtKB/TrEMBL
      D5SHR2
      Related
      FBpp0082496
      Conserved Domains (1) summary
      pfam05693
      Location:53 → 697
      Glycogen_syn; Glycogen synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHJ5 A0A0B4KHJ5
    Q9VFC8.2 Q9VFC8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous