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    PGRP-LB Peptidoglycan recognition protein LB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41379, updated on 10-May-2024

    Summary

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    Official Symbol
    PGRP-LBprovided by FlyBase
    Official Full Name
    Peptidoglycan recognition protein LBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037906
    Locus tag
    Dmel_CG14704
    See related
    AllianceGenome:FB:FBgn0037906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14704; Dmel\CG14704; PGRP; pgrp-lb; pgrp-LB
    Summary
    Enables N-acetylmuramoyl-L-alanine amidase activity. Involved in defense response to Gram-positive bacterium; negative regulation of defense response to bacterium; and peptidoglycan catabolic process. Located in extracellular region. Is expressed in several structures, including adult and gut. Orthologous to human PGLYRP2 (peptidoglycan recognition protein 2) and PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See PGRP-LB in Genome Data Viewer
    Location:
    86E6-86E6; 3-51 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (11452849..11460552, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (7278571..7286274, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene sarcomere length short Neighboring gene mir-4945 stem loop Neighboring gene long non-coding RNA:CR45581 Neighboring gene defective proboscis extension response 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction. Orlans J, et al. Int J Mol Sci, 2021 May 7. PMID 34066955, Free PMC Article
    2. Maternal Priming of Offspring Immune System in Drosophila. Bozler J, et al. G3 (Bethesda), 2020 Jan 7. PMID 31685524, Free PMC Article
    3. Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster. Vincent CM, et al. Proc Natl Acad Sci U S A, 2021 Aug 10. PMID 34341118, Free PMC Article
    4. Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution. Reiser JB, et al. J Mol Biol, 2004 Jul 16. PMID 15223330
    5. Crystal structure of peptidoglycan recognition protein LB from Drosophila melanogaster. Kim MS, et al. Nat Immunol, 2003 Aug. PMID 12845326

    See all (143) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster.
      Title: Disparate regulation of IMD signaling drives sex differences in infection pathology in Drosophila melanogaster.
    2. PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
      Title: PGRP-LB: An Inside View into the Mechanism of the Amidase Reaction.
    3. The data show that the PGRP-LB locus can produce cytosolic and extracellular proteins that both buffer the effects of gut-bacteria-derived Peptidoglycan.
      Title: Cytosolic and Secreted Peptidoglycan-Degrading Enzymes in Drosophila Respectively Control Local and Systemic Immune Responses to Microbiota.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-acetylmuramoyl-L-alanine amidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylmuramoyl-L-alanine amidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylmuramoyl-L-alanine amidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables peptidoglycan binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peptidoglycan catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in peptidoglycan catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    peptidoglycan recognition protein LB
    Names
    CG14704-PA
    CG14704-PB
    CG14704-PC
    CG14704-PD
    CG14704-PE
    CG14704-PF
    PGRP-LB-PA
    PGRP-LB-PB
    PGRP-LB-PC
    PGRP-LB-PD
    PGRP-LB-PE
    PGRP-LB-PF
    Peptidoglycan-recognition protein-LB precursor
    NP_001247052.1
    NP_001247053.1
    NP_001247054.1
    NP_650079.1
    NP_731575.1
    NP_731576.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      11452849..11460552 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260123.1 → NP_001247052.1  peptidoglycan recognition protein LB, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247052.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K741
      Conserved Domains (1) summary
      smart00701
      Location:53 → 195
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    2. NM_169392.2 → NP_731575.1  peptidoglycan recognition protein LB, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731575.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INK6, Q9VGN3
      Related
      FBpp0081872
      Conserved Domains (1) summary
      smart00701
      Location:30 → 172
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    3. NM_001260124.2 → NP_001247053.1  peptidoglycan recognition protein LB, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247053.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2P5
      Conserved Domains (1) summary
      smart00701
      Location:13 → 155
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    4. NM_169393.3 → NP_731576.1  peptidoglycan recognition protein LB, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731576.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2P5
      Related
      FBpp0081873
      Conserved Domains (1) summary
      smart00701
      Location:13 → 155
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    5. NM_141822.3 → NP_650079.1  peptidoglycan recognition protein LB, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650079.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2P5
      Related
      FBpp0081874
      Conserved Domains (1) summary
      smart00701
      Location:13 → 155
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme

    6. NM_001260125.2 → NP_001247054.1  peptidoglycan recognition protein LB, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247054.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4V2P5
      Conserved Domains (1) summary
      smart00701
      Location:13 → 155
      PGRP; Animal peptidoglycan recognition proteins homologous to Bacteriophage T3 lysozyme
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K741 A0A0B4K741
    A4V2P5 A4V2P5
    Q8INK6.1 Q8INK6

    Gene LinkOut

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