eIF6 eukaryotic translation initiation factor 6 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: eIF6provided by FlyBase
Official Full Name: eukaryotic translation initiation factor 6provided by FlyBase
Primary source: FLYBASE:FBgn0034915
Locus tag: Dmel_CG17611
See related: AllianceGenome:FB:FBgn0034915
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0172774.153; anon-WO0172774.155; CG17611; DeIF6; Dmel\CG17611; eif6; EIF6; elF6; l(2)k13214
Summary: Predicted to enable ribosomal large subunit binding activity and translation initiation factor activity. Predicted to be involved in assembly of large subunit precursor of preribosome; ribosome biogenesis; and translational initiation. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in cytosol and nucleolus. Is expressed in several structures, including embryonic/larval midgut; embryonic/larval midgut primordium; embryonic/larval muscle system; larval imaginal tissue; and trunk mesoderm. Orthologous to human EIF6 (eukaryotic translation initiation factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23849246..23850301, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19736769..19737824, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ribosomal large subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables ribosome binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in assembly of large subunit precursor of preribosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytosolic ribosome assembly	IEA Inferred from Electronic Annotation more info
involved_in maturation of 5.8S rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in maturation of LSU-rRNA	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

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