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    CLUL1 clusterin like 1 [ Homo sapiens (human) ]

    Gene ID: 27098, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CLUL1provided by HGNC
    Official Full Name
    clusterin like 1provided by HGNC
    Primary source
    HGNC:HGNC:2096
    See related
    Ensembl:ENSG00000079101 MIM:616990; AllianceGenome:HGNC:2096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RA337M
    Summary
    Predicted to enable misfolded protein binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in prostate (RPKM 1.3), thyroid (RPKM 0.8) and 10 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    18p11.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (596988..650182)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (751354..804514)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (596988..650182)

    Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 146 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:596737-596866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:597469-597968 Neighboring gene centrin 1 Neighboring gene Sharpr-MPRA regulatory region 12053 Neighboring gene uncharacterized LOC105371952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:641155-642354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657377-657878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657879-658378 Neighboring gene TYMS opposite strand RNA Neighboring gene enolase superfamily member 1 Neighboring gene thymidylate synthetase Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:686134-686722 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:697612-697744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:712826-713405 Neighboring gene Sharpr-MPRA regulatory region 6782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13022 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene RNA, U1 small nuclear 109, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Zhang Q, et al. Invest Ophthalmol Vis Sci, 2003 Oct. PMID 14507903
    2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. Zhang Q, et al. Gene, 2000 Feb 8. PMID 10675623
    3. Mapping of transcription start sites of human retina expressed genes. Roni V, et al. BMC Genomics, 2007 Feb 7. PMID 17286855, Free PMC Article
    4. RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Pang K, et al. Nat Commun, 2019 Dec 20. PMID 31862882, Free PMC Article
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables misfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    clusterin-like protein 1
    Names
    clusterin-like 1 (retinal)
    retinal clusterin-like protein
    retinal-specific clusterin-like protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289036.3 → NP_001275965.2  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Related
      ENSP00000441726.2, ENST00000540035.5
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    2. NM_001318522.2 → NP_001305451.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Related
      ENSP00000464642.1, ENST00000579494.1
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    3. NM_001375492.2 → NP_001362421.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    4. NM_001393344.1 → NP_001380273.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Related
      ENSP00000510271.1, ENST00000692774.1
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    5. NM_001393345.1 → NP_001380274.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    6. NM_001393346.1 → NP_001380275.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    7. NM_001393347.1 → NP_001380276.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    8. NM_001393348.1 → NP_001380277.1  clusterin-like protein 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    9. NM_014410.6 → NP_055225.1  clusterin-like protein 1 precursor

      See identical proteins and their annotated locations for NP_055225.1

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Related
      ENSP00000383449.2, ENST00000400606.6
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    10. NM_199167.2 → NP_954636.1  clusterin-like protein 1 precursor

      See identical proteins and their annotated locations for NP_954636.1

      Status: VALIDATED

      Source sequence(s)
      AP001178
      Consensus CDS
      CCDS42405.1
      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
      UniProtKB/TrEMBL
      J3QKW8
      Related
      ENSP00000341128.6, ENST00000338387.11
      Conserved Domains (1) summary
      pfam01093
      Location:33 → 462
      Clusterin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

      Range
      596988..650182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011525651.3 → XP_011523953.1  clusterin-like protein 1 isoform X2

      See identical proteins and their annotated locations for XP_011523953.1

      UniProtKB/TrEMBL
      J3QKW8
      Conserved Domains (3) summary
      smart00030
      Location:37 → 248
      CLb; CLUSTERIN Beta chain
      smart00035
      Location:249 → 471
      CLa; CLUSTERIN alpha chain
      pfam01093
      Location:44 → 473
      Clusterin; Clusterin

    2. XM_011525648.4 → XP_011523950.2  clusterin-like protein 1 isoform X1

      Related
      ENSP00000463269.2, ENST00000581619.5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060942.1 Alternate T2T-CHM13v2.0

      Range
      751354..804514
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054318530.1 → XP_054174505.1  clusterin-like protein 1 isoform X2

    2. XM_054318526.1 → XP_054174501.1  clusterin-like protein 1 isoform X3

    3. XM_054318529.1 → XP_054174504.1  clusterin-like protein 1 isoform X4

    4. XM_054318527.1 → XP_054174502.1  clusterin-like protein 1 isoform X3

    5. XM_054318528.1 → XP_054174503.1  clusterin-like protein 1 isoform X3

    6. XM_054318531.1 → XP_054174506.1  clusterin-like protein 1 isoform X5

      UniProtKB/Swiss-Prot
      A0FDN7, Q15846
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q15846.1 GenPept UniProtKB/Swiss-Prot:Q15846

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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