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    EIF3M eukaryotic translation initiation factor 3 subunit M [ Homo sapiens (human) ]

    Gene ID: 10480, updated on 7-Apr-2024

    Summary

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    Official Symbol
    EIF3Mprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Mprovided by HGNC
    Primary source
    HGNC:HGNC:24460
    See related
    Ensembl:ENSG00000149100 MIM:609641; AllianceGenome:HGNC:24460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    B5; GA17; PCID1; TANGO7; hfl-B5
    Summary
    This gene encodes a protein that is part of the eurkaryotic translation initiation factor 3 complete (eIF-3) required for protein synthesis. Elevated levels of the encoded protein are present in cancer cell lines. Inactivation of the encoded protein has been shown to interfere with translation of herpes virus mRNAs by preventing the association of mRNAs with the ribosomes. A pseudogene of this gene is located on the X chromosome. [provided by RefSeq, Dec 2011]
    Expression
    Ubiquitous expression in ovary (RPKM 68.3), thyroid (RPKM 54.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    11p13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (32583831..32606264)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (32719345..32741774)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (32605377..32627810)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene thioesterase superfamily member 7, pseudogene Neighboring gene small nucleolar RNA, H/ACA box 88 Neighboring gene HCNE2 enhancer upstream of PAX6 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:32380174-32380395 Neighboring gene WT1 3' enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3221 Neighboring gene WT1 intron 3 regulatory region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32449464-32450078 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:32450079-32450691 Neighboring gene WT1/WT1-AS bi-directional promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32459559-32460416 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:32460417-32461272 Neighboring gene Sharpr-MPRA regulatory region 1868 Neighboring gene WT1 transcription factor Neighboring gene MPRA-validated peak1243 silencer Neighboring gene WT1 antisense RNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4564 Neighboring gene MPRA-validated peak1244 silencer Neighboring gene MPRA-validated peak1246 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:32605088-32605740 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3223 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene 9 Neighboring gene coiled-coil domain containing 73 Neighboring gene 60S ribosomal protein L34-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3224 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3225 Neighboring gene ribosomal protein L34 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4566 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4567 Neighboring gene proline rich and Gla domain 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer. Goh SH, et al. Oncogene, 2011 Jan 27. PMID 20838379
    2. HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target. Cheshenko N, et al. PLoS One, 2010 Jul 27. PMID 20676407, Free PMC Article
    3. The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection. Perez-Romero P, et al. J Virol, 2005 Jun. PMID 15919899, Free PMC Article
    4. A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins. Perez A, et al. J Virol, 2005 Jun. PMID 15919898, Free PMC Article
    5. A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3. Proshkin SA, et al. Biochemistry (Mosc), 2011 Aug. PMID 22022972

    See all (124) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. POLR2J interacts with three different subunits of eIF3, eIF3a, eIF3i, and eIF3m.
      Title: A minor isoform of the human RNA polymerase II subunit hRPB11 (POLR2J) interacts with several components of the translation initiation factor eIF3.
    2. eIF3m mediates regulation of tumorigenesis-related genes in human colon cancer
      Title: eIF3m expression influences the regulation of tumorigenesis-related genes in human colon cancer.
    3. Results demonstrate that B5 plays a major role in the initiation of HSV protein translation and could provide a novel target for strategies to prevent primary and recurrent herpetic disease.
      Title: HSV usurps eukaryotic initiation factor 3 subunit M for viral protein translation: novel prevention target.
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    5. the human Tango7 counterpart, PCID1 (also known as EIF3M), impinged on caspase 9, revealing a new regulatory axis affecting the apoptosome
      Title: Genome-wide silencing in Drosophila captures conserved apoptotic effectors.
    6. Concluded that the C terminus of B5 contains a functional region that is important for the B5 receptor to mediate events in HSV entry.
      Title: The C terminus of the B5 receptor for herpes simplex virus contains a functional region important for infection.
    7. Cloned a previously uncharacterized human gene, designated hfl-B5, and showed that it encodes a type II cell surface membrane protein that can serve as a receptor for entry of HSV.
      Title: A new class of receptor for herpes simplex virus has heptad repeat motifs that are common to membrane fusion proteins.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 3, subunit M (EIF3M), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF3M is decreased by RRE PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit M (EIF3M) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ29030

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex, eIF3m IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit M
    Names
    B5 receptor
    PCI domain containing 1 (herpesvirus entry mediator)
    PCI domain-containing protein 1
    dendritic cell protein
    fetal lung protein B5
    transport and golgi organization 7 homolog
    NP_001294858.1
    NP_006351.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001307929.2 → NP_001294858.1  eukaryotic translation initiation factor 3 subunit M isoform 2

      See identical proteins and their annotated locations for NP_001294858.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks in-frame exons in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AK292139, AK304378, AL078477, AV713889, BE935691, CK002866, DB479224
      Consensus CDS
      CCDS76392.1
      UniProtKB/TrEMBL
      H0YCQ8
      Related
      ENSP00000436787.1, ENST00000524896.5
      Conserved Domains (1) summary
      smart00088
      Location:137 → 225
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    2. NM_006360.6 → NP_006351.2  eukaryotic translation initiation factor 3 subunit M isoform 1

      See identical proteins and their annotated locations for NP_006351.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK304378, AL078477, BC019103, BE935691, CK002866, DB479224
      Consensus CDS
      CCDS7880.1
      UniProtKB/Swiss-Prot
      A8K7X4, B4E2Q4, O60735, Q2F836, Q53HL6, Q7L2H7, Q9BXW1
      Related
      ENSP00000436049.1, ENST00000531120.6
      Conserved Domains (1) summary
      smart00088
      Location:269 → 357
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      32583831..32606264
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      32719345..32741774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L2H7.1 GenPept UniProtKB/Swiss-Prot:Q7L2H7

    Gene LinkOut

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