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    Jabba [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37164, updated on 27-Mar-2024

    Summary

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    Official Symbol
    Jabbaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0259682
    Locus tag
    Dmel_CG42351
    See related
    AllianceGenome:FB:FBgn0259682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141242_at; anon-WO0118547.167; BP1008; CG15092; CG34020; CG42351; Dmel\CG42351; jabba
    Old locus tag
    Dmel_CG15092; Dmel_CG34020
    Summary
    Involved in lipid homeostasis. Located in lipid droplet. Is expressed in adult head; nurse cell; oocyte; and organism. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    55F1-55F1; 2-86 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18757074..18761082, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14644579..14648587, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate 3-O sulfotransferase-A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12b2 Neighboring gene transfer RNA:Leucine-AAG 1-4 Neighboring gene Multiple C2 domain and transmembrane region protein Neighboring gene antisense RNA:CR43964 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development. Li Z, et al. Curr Biol, 2014 Jul 7. PMID 24930966, Free PMC Article
    2. A novel role for lipid droplets in the organismal antibacterial response. Anand P, et al. Elife, 2012 Nov 13. PMID 23150794, Free PMC Article
    3. Sequestration to lipid droplets promotes histone availability by preventing turnover of excess histones. Stephenson RA, et al. Development, 2021 Aug 1. PMID 34355743, Free PMC Article
    4. Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in Drosophila embryos. Johnson MR, et al. Elife, 2018 Jul 25. PMID 30044219, Free PMC Article
    5. Temporal control of bidirectional lipid-droplet motion in Drosophila depends on the ratio of kinesin-1 and its co-factor Halo. Arora GK, et al. J Cell Sci, 2016 Apr 1. PMID 26906417, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
      Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
    2. In targeted experiments, authors analyzed the two proteins Jabba and CG9186 in greater detail. Jabba mediates the sequestration of histones to lipid droplets.
      Title: A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions.
    3. Excess core histone H2A and the histone variant H2Av, generated during oogenesis, are anchored to lipid droplets via Jabba.
      Title: Drosophila lipid droplets buffer the H2Av supply to protect early embryonic development.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    jabba
    Names
    CG42351-PB
    CG42351-PC
    CG42351-PD
    CG42351-PE
    CG42351-PF
    CG42351-PG
    CG42351-PH
    CG42351-PI
    Jabba-PB
    Jabba-PC
    Jabba-PD
    Jabba-PE
    Jabba-PF
    Jabba-PG
    Jabba-PH
    Jabba-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      18757074..18761082 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274147.1 → NP_001261076.1  jabba, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261076.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KG78, K4GUH7
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    2. NM_001202042.2 → NP_001188971.1  jabba, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188971.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZK4, K4GUH7
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    3. NM_001274148.1 → NP_001261077.1  jabba, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261077.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFV2, K4GUH7
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    4. NM_001144231.3 → NP_001137703.1  jabba, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137703.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZK5
      Conserved Domains (2) summary
      pfam12287
      Location:367 → 532
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    5. NM_001202041.2 → NP_001188970.1  jabba, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188970.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCT7
      Conserved Domains (2) summary
      pfam12287
      Location:344 → 509
      Caprin-1_C; Cytoplasmic activation/proliferation-associated protein-1 C term
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    6. NM_001144233.2 → NP_001137705.1  jabba, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137705.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZK4, K4GUH7
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    7. NM_001144232.4 → NP_001137704.1  jabba, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001137704.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B7YZK6
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)

    8. NM_137527.4 → NP_611371.1  jabba, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611371.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1Q6
      Related
      FBpp0289219
      Conserved Domains (1) summary
      pfam16091
      Location:38 → 235
      DUF4820; Domain of unknown function (DUF4820)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCT7 A0A0B4JCT7
    A0A0B4KFV2 A0A0B4KFV2
    A0A0B4KG78 A0A0B4KG78
    B7YZK4 B7YZK4
    B7YZK5 B7YZK5
    B7YZK6 B7YZK6
    Q7K1Q6 Q7K1Q6

    Gene LinkOut

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