Plpp6 phospholipid phosphatase 6 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Plpp6provided by RGD
Official Full Name: phospholipid phosphatase 6provided by RGD
Primary source: RGD:1566000
See related: Ensembl:ENSRNOG00000015268 AllianceGenome:RGD:1566000
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ppapdc2
Summary: Predicted to enable sphingosine-1-phosphate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation. Predicted to be integral component of membrane. Predicted to be active in membrane. Orthologous to human PLPP6 (phospholipid phosphatase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (236092642..236095494)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (226679100..226681952)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (247084228..247087080)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables isoprenoid diphosphate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lipid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	ISO Inferred from Sequence Orthology more info
enables lysophosphatidic acid phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidate phosphatase activity	ISO Inferred from Sequence Orthology more info
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in farnesyl diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesyl diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in geranyl diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in geranyl diphosphate metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in geranylgeranyl diphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in geranylgeranyl diphosphate catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in isoprenoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil activation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

Names: phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; presqualene diphosphate phosphatase

NP_001030026.1

EC 3.6.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034854.1 → NP_001030026.1 polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6

See identical proteins and their annotated locations for NP_001030026.1

Status: PROVISIONAL

Source sequence(s)

BC081970

UniProtKB/Swiss-Prot

Q66H88

Related

ENSRNOP00000020475.3, ENSRNOT00000020475.5

Conserved Domains (2) summary

COG0671
Location:206 → 267

PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]

cd03391
Location:116 → 274

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...