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    Parp3 poly (ADP-ribose) polymerase family, member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300985, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Parp3provided by RGD
    Official Full Name
    poly (ADP-ribose) polymerase family, member 3provided by RGD
    Primary source
    RGD:1305189
    See related
    Ensembl:ENSRNOG00000012865 AllianceGenome:RGD:1305189
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Adprtl3
    Summary
    Predicted to enable NAD DNA ADP-ribosyltransferase activity; NAD+ ADP-ribosyltransferase activity; and protein ADP-ribosylase activity. Predicted to be involved in DNA metabolic process; protein ADP-ribosylation; and regulation of DNA metabolic process. Predicted to act upstream of or within several processes, including positive regulation of DNA ligation; protein localization to site of double-strand break; and regulation of mitotic spindle organization. Predicted to be located in intercellular bridge and nuclear body. Predicted to be active in nucleolus and site of double-strand break. Orthologous to human PARP3 (poly(ADP-ribose) polymerase family member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 112.7), Muscle (RPKM 100.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q32
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (115989721..115995822, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (107111010..107117073, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (115173440..115179543, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene abhydrolase domain containing 14b Neighboring gene poly(rC) binding protein 4 Neighboring gene G protein-coupled receptor 62 Neighboring gene ribosomal RNA processing 9, U3 small nucleolar RNA binding protein Neighboring gene IQ motif containing F1 Neighboring gene IQ motif containing F5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways. Beck C, et al. Nucleic Acids Res, 2014 May. PMID 24598253, Free PMC Article
    2. Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation. Zarkovic G, et al. Nucleic Acids Res, 2018 Mar 16. PMID 29361132, Free PMC Article
    3. Parp3 negatively regulates immunoglobulin class switch recombination. Robert I, et al. PLoS Genet, 2015 May. PMID 26000965, Free PMC Article
    4. Poly (ADP-ribose) polymerase 3 (PARP3), a potential repressor of telomerase activity. Fernández-Marcelo T, et al. J Exp Clin Cancer Res, 2014 Feb 15. PMID 24528514, Free PMC Article
    5. PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA. Loseva O, et al. J Biol Chem, 2010 Mar 12. PMID 20064938, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC94593

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD DNA ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+- protein-aspartate ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+- protein-lysine ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+-protein ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables NAD+-protein-glutamate ADP-ribosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within double-strand break repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of isotype switching ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA ligation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of double-strand break repair via nonhomologous end joining ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein auto-ADP-ribosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization to site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein poly-ADP-ribosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of mitotic spindle organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within telomere maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in site of double-strand break IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein mono-ADP-ribosyltransferase PARP3
    Names
    ADP-ribosyltransferase (NAD+, poly (ADP-ribose polymerase)-like 3
    poly (ADP-ribosyl) transferase-like 3
    poly [ADP-ribose] polymerase 3
    NP_001008329.1
    XP_006243787.1
    XP_008764722.1
    XP_038937138.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008328.1 → NP_001008329.1  protein mono-ADP-ribosyltransferase PARP3

      See identical proteins and their annotated locations for NP_001008329.1

      Status: PROVISIONAL

      Source sequence(s)
      BC085863
      UniProtKB/TrEMBL
      A0A8I5ZLL0, F1LPC9, Q5U2U3
      Conserved Domains (2) summary
      cd01437
      Location:175 → 525
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56 → 154
      WGR; WGR domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      115989721..115995822 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766500.3 → XP_008764722.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      See identical proteins and their annotated locations for XP_008764722.1

      UniProtKB/TrEMBL
      A0A8J8XBZ3
      Related
      ENSRNOP00000017224.7
      Conserved Domains (3) summary
      cd01437
      Location:180 → 530
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:328 → 530
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl01581
      Location:56 → 154
      WGR; WGR domain

    2. XM_039081210.2 → XP_038937138.1  protein mono-ADP-ribosyltransferase PARP3 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZLL0, F1LPC9, Q5U2U3
      Related
      ENSRNOP00000078842.1
      Conserved Domains (2) summary
      cd01437
      Location:175 → 525
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      cl01581
      Location:56 → 154
      WGR; WGR domain

    3. XM_006243725.5 → XP_006243787.1  protein mono-ADP-ribosyltransferase PARP3 isoform X1

      See identical proteins and their annotated locations for XP_006243787.1

      UniProtKB/TrEMBL
      A0A8J8XBZ3
      Conserved Domains (3) summary
      cd01437
      Location:180 → 530
      parp_like; Poly(ADP-ribose) polymerase (parp) catalytic domain catalyses the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a ...
      pfam00644
      Location:328 → 530
      PARP; Poly(ADP-ribose) polymerase catalytic domain
      cl01581
      Location:56 → 154
      WGR; WGR domain
    Nucleotide Protein Strain
    Heading Accession and Version

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