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    QDR3 Qdr3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852331, updated on 17-May-2024

    Summary

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    Gene symbol
    QDR3
    Gene description
    Qdr3p
    Primary source
    FungiDB:YBR043C
    Locus tag
    YBR043C
    See related
    SGD:S000000247; AllianceGenome:SGD:S000000247; VEuPathDB:YBR043C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AQR2
    Summary
    Enables efflux transmembrane transporter activity and polyamine transmembrane transporter activity. Involved in ascospore wall assembly; polyamine homeostasis; and transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See QDR3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (321876..323945, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene long-chain fatty acid transporter FAT1 Neighboring gene putative acyltransferase Neighboring gene Tcm62p Neighboring gene tRNA-Val

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast cells with impaired drug resistance accumulate glycerol and glucose. Dikicioglu D, et al. Mol Biosyst, 2014 Jan. PMID 24157722
    2. Overlapping Roles of Yeast Transporters Aqr1, Qdr2, and Qdr3 in Amino Acid Excretion and Cross-Feeding of Lactic Acid Bacteria. Kapetanakis GC, et al. Front Microbiol, 2021. PMID 34887841, Free PMC Article
    3. Improvement of acetic acid tolerance of Saccharomyces cerevisiae using a zinc-finger-based artificial transcription factor and identification of novel genes involved in acetic acid tolerance. Ma C, et al. Appl Microbiol Biotechnol, 2015 Mar. PMID 25698512
    4. The yeast multidrug transporter Qdr3 (Ybr043c): localization and role as a determinant of resistance to quinidine, barban, cisplatin, and bleomycin. Tenreiro S, et al. Biochem Biophys Res Commun, 2005 Feb 18. PMID 15649438
    5. Yeast response and tolerance to polyamine toxicity involving the drug : H+ antiporter Qdr3 and the transcription factors Yap1 and Gcn4. Teixeira MC, et al. Microbiology (Reading), 2011 Apr. PMID 21148207

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables polyamine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polyamine transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables threonine efflux transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid export across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ascospore wall assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular polyamine homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular polyamine homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in polyamine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in threonine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Qdr3p
    NP_009599.2
    • Multidrug transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; has a role in polyamine homeostasis; involved in spore wall asembly; sequence similarity to DTR1 and QDR1, and the triple mutant dtr1 qdr1 qdr3 exhibits reduced dityrosine fluorescence relative to the single mutants; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      321876..323945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178391.2 → NP_009599.2  TPA: Qdr3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009599.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQ43, P38227
      UniProtKB/TrEMBL
      A0A8H4F6J5, C7GXW9, D3UED8, N1P6G2
      Conserved Domains (1) summary
      cd17323
      Location:110 → 676
      MFS_Tpo1_MDR_like; Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38227.2

    Gene LinkOut

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