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    ATP20 F1F0 ATP synthase subunit g [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856131, updated on 9-Jun-2024

    Summary

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    Gene symbol
    ATP20
    Gene description
    F1F0 ATP synthase subunit g
    Primary source
    FungiDB:YPR020W
    Locus tag
    YPR020W
    See related
    SGD:S000006224; AllianceGenome:SGD:S000006224; VEuPathDB:YPR020W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to proton-transporting ATP synthase activity, rotational mechanism. Involved in ATP synthesis coupled proton transport; cristae formation; and protein-containing complex assembly. Located in mitochondrion. Part of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o). Orthologous to human ATP5MG (ATP synthase membrane subunit g) and ATP5MGL (ATP synthase membrane subunit g like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ATP20 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (599870..600217)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Rlf2p Neighboring gene MCM DNA helicase complex subunit MCM4 Neighboring gene citrin Neighboring gene Sdd4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kinetic coupling of the respiratory chain with ATP synthase, but not proton gradients, drives ATP production in cristae membranes. Toth A, et al. Proc Natl Acad Sci U S A, 2020 Feb 4. PMID 31964824, Free PMC Article
    2. Identification of subunit g of yeast mitochondrial F1F0-ATP synthase, a protein required for maximal activity of cytochrome c oxidase. Boyle GM, et al. Eur J Biochem, 1999 Jun. PMID 10336613
    3. Arg-8 of yeast subunit e contributes to the stability of F-ATP synthase dimers and to the generation of the full-conductance mitochondrial megachannel. Guo L, et al. J Biol Chem, 2019 Jul 12. PMID 31160339, Free PMC Article
    4. Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization. Wagner K, et al. J Mol Biol, 2009 Oct 2. PMID 19635484
    5. The intermembrane space loop of subunit b (4) is a major determinant of the stability of yeast oligomeric ATP synthases. Weimann T, et al. Biochemistry, 2008 Mar 18. PMID 18293929

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that Su k (Atp19) and Su i (Atp18) are involved in the assembly of Su e (Atp21) and Su g (Atp20) F(1)F(o)-ATP synthase dimers and oligomers.
      Title: Stepwise assembly of dimeric F(1)F(o)-ATP synthase in mitochondria involves the small F(o)-subunits k and i.
    2. Association of Su e and Su g with monomeric F(1)F(o)-ATP synthase represents an initial step of oligomer formation.
      Title: Mitochondrial F1Fo-ATP synthase: the small subunits e and g associate with monomeric complexes to trigger dimerization.
    3. Results propose a model in which the antagonism between Fcj1 and Su e/g locally modulates the F(1)F(O) oligomeric state, thereby controlling membrane curvature of cristae to generate crista junctions and cristae tips.
      Title: Formation of cristae and crista junctions in mitochondria depends on antagonism between Fcj1 and Su e/g.
    4. the GXXXG motif may not be the sole basis for a Su g-Su e interaction within F1F0-ATPase
      Title: The yeast F(1)F(0)-ATP synthase: analysis of the molecular organization of subunit g and the importance of a conserved GXXXG motif.
    5. the conserved GXXXG motif of the membrane-spanning segment of subunit g has a role in the supramolecular species of yeast ATP synthase
      Title: The modification of the conserved GXXXG motif of the membrane-spanning segment of subunit g destabilizes the supramolecular species of yeast ATP synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables proton transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cristae formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein-containing complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    F1F0 ATP synthase subunit g
    NP_015345.1
    • Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex, which in turn determines oligomerization of the complex and the shape of inner membrane cristae

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      599870..600217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184117.1 → NP_015345.1  TPA: F1F0 ATP synthase subunit g [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015345.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W430, Q12233
      UniProtKB/TrEMBL
      A0A6A5Q5A2, A6ZWR3, B3LL81, C7GQB8, C8ZJ45, G2WPJ8, N1NVJ4
      Conserved Domains (1) summary
      pfam04718
      Location:14 → 112
      ATP-synt_G; Mitochondrial ATP synthase g subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12233.1

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