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    nfya nuclear transcription factor Y, alpha [ Danio rerio (zebrafish) ]

    Gene ID: 83915, updated on 27-Mar-2024

    Summary

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    Official Symbol
    nfyaprovided by ZNC
    Official Full Name
    nuclear transcription factor Y, alphaprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-010501-1
    See related
    Ensembl:ENSDARG00000042004 AllianceGenome:ZFIN:ZDB-GENE-010501-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fb16e03; tdsubc_2b6; wu:fb16e03; ik:tdsubc_2b6; xx:tdsubc_2b6
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of CCAAT-binding activity factor complex. Orthologous to human NFYA (nuclear transcription factor Y subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See nfya in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (36254948..36279623, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (35993022..36017632, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene si:ch211-213o11.11 Neighboring gene caveolin 4a Neighboring gene sortilin 1a Neighboring gene proteasome 20S subunit alpha 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation. Chen J. Genesis, 2021 Feb. PMID 33417743
    2. Combinatorial action of NF-Y and TALE at embryonic enhancers defines distinct gene expression programs during zygotic genome activation in zebrafish. Stanney W 3rd, et al. Dev Biol, 2020 Mar 15. PMID 31862379, Free PMC Article
    3. MITO-Luc/GFP zebrafish model to assess spatial and temporal evolution of cell proliferation in vivo. de Latouliere L, et al. Sci Rep, 2021 Jan 12. PMID 33436662, Free PMC Article
    4. Novel and unexpected functions of zebrafish CCAAT box binding transcription factor (NF-Y) B subunit during cartilages development. Chen YH, et al. Bone, 2009 May. PMID 19442608
    5. Maternal methylmercury from a wild-caught walleye diet induces developmental abnormalities in zebrafish. Liu Q, et al. Reprod Toxicol, 2016 Oct. PMID 27544571

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation.
      Title: NF-Y is critical for the proper growth of zebrafish embryonic heart and its cardiomyocyte proliferation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of CCAAT-binding factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of CCAAT-binding factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nuclear transcription factor Y subunit alpha

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001082795.1 → NP_001076264.1  nuclear transcription factor Y subunit alpha

      See identical proteins and their annotated locations for NP_001076264.1

      Status: PROVISIONAL

      Source sequence(s)
      BC133845
      UniProtKB/TrEMBL
      A0A8M1ND49, A3KNH7
      Related
      ENSDARP00000093838.3, ENSDART00000103064.5
      Conserved Domains (1) summary
      pfam02045
      Location:232 → 286
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      36254948..36279623 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009306191.3 → XP_009304466.1  nuclear transcription factor Y subunit alpha isoform X3

      UniProtKB/TrEMBL
      A0A8M3B482, E9QGB7
      Related
      ENSDARP00000106116.3, ENSDART00000125616.4
      Conserved Domains (1) summary
      pfam02045
      Location:257 → 311
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    2. XM_009306192.3 → XP_009304467.1  nuclear transcription factor Y subunit alpha isoform X4

      UniProtKB/TrEMBL
      A0A8M3AXW0
      Conserved Domains (1) summary
      pfam02045
      Location:245 → 299
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    3. XM_005172907.4 → XP_005172964.1  nuclear transcription factor Y subunit alpha isoform X2

      UniProtKB/TrEMBL
      A0A8M2BKP2
      Conserved Domains (1) summary
      pfam02045
      Location:256 → 310
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    4. XM_009306188.3 → XP_009304463.1  nuclear transcription factor Y subunit alpha isoform X1

      See identical proteins and their annotated locations for XP_009304463.1

      UniProtKB/TrEMBL
      A0A8M3B723
      Conserved Domains (1) summary
      pfam02045
      Location:257 → 311
      CBFB_NFYA; CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394825.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      215229..232006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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