Orm1 orosomucoid 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Orm1provided by MGI
Official Full Name: orosomucoid 1provided by MGI
Primary source: MGI:MGI:97443
See related: Ensembl:ENSMUSG00000039196 AllianceGenome:MGI:97443
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Agp-1; Agp-2; Orm-1
Summary: This gene encodes a member of the lipocalin family of proteins. The encoded protein is an abundant acute-phase protein that is synthesized by hepatocytes in response to cytokines during the acute phase response. The encoded protein may regulate inflammation and metabolism. This gene is present in a gene cluster on chromosome 4. [provided by RefSeq, Aug 2015]
Expression: Biased expression in liver adult (RPKM 234.2), subcutaneous fat pad adult (RPKM 106.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B3; 4 33.96 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (63262793..63266400)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (63344556..63348163)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis.
Title: Orosomucoid-1 Arises as a Shared Altered Protein in Two Models of Multiple Sclerosis.
Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization.
Title: Orosomucoid 1 promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing macrophage M2 polarization.
alpha1-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages.
Title: α(1)-Acid Glycoprotein Enhances the Immunosuppressive and Protumor Functions of Tumor-Associated Macrophages.
The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
Title: The bile acid induced hepatokine orosomucoid suppresses adipocyte differentiation.
Data provide evidence that Orm1 is induced in response to hepatic injury and executes liver regeneration by activating cell cycle progression in hepatocytes.
Title: Transcriptome Analysis Uncovers a Growth-Promoting Activity of Orosomucoid-1 on Hepatocytes.
This study demonstrated that decreasing the Orm1 expression via inhibition of the NF-kappaB pathway could be a possible mechanism involved in the aggravation of BBB disruption after stroke by VEGF.
Title: Orosomucoid1: Involved in vascular endothelial growth factor-induced blood-brain barrier leakage after ischemic stroke in mouse.
alpha(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Title: α(1)-Acid glycoprotein up-regulates CD163 via TLR4/CD14 protein pathway: possible protection against hemolysis-induced oxidative stress.
Together, these data suggest that alpha1-acid glycoprotein may be involved in reduction of neutrophil migration and increased susceptibility to sepsis in diabetic mice.
Title: α1-Acid glycoprotein decreases neutrophil migration and increases susceptibility to sepsis in diabetic mice.
ORM integrates inflammatory and metabolic signals to modulate immune responses to protect adipose tissue from excessive inflammation and thereby from metabolic dysfunction.
Title: Adipocytokine orosomucoid integrates inflammatory and metabolic signals to preserve energy homeostasis by resolving immoderate inflammation.
alpha-1 acid glycoprotein expression is increased by retinoids at the transcriptional level through two distinct DR1 retinoic acid responsive elements
Title: Retinoids increase alpha-1 acid glycoprotein expression at the transcriptional level through two distinct DR1 retinoic acid responsive elements.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW110443 (e-PCR)
- UniSTS:207629

Orm1 (e-PCR), detects polymorphism
- UniSTS:144095

Orm1 (e-PCR), detects polymorphism
- UniSTS:144096

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables small molecule binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acute-phase response	IEA Inferred from Electronic Annotation more info
involved_in regulation of immune system process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alpha-1-acid glycoprotein 1

Names: AGP 1; OMD 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.