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    cheA chemotaxis protein CheA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946401, updated on 2-May-2024

    Summary

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    Gene symbol
    cheA
    Gene description
    chemotaxis protein CheA
    Primary source
    ASAP:ABE-0006294
    Locus tag
    b1888
    See related
    ECOCYC:EG10146
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1889
    Summary
    CheAS is required for polar localization of CheZ. [More information is available at EcoGene: EG10146]. The cheA gene encodes two forms, large and small, of an almost identical polypeptide. [More information is available at EcoCyc: EG10146].
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    Genomic context

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    Sequence:
    NC_000913.3 (1973360..1975324, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene methyl-accepting chemotaxis protein Tar Neighboring gene chemotaxis protein CheW Neighboring gene motility protein B Neighboring gene motility protein A Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator FlhC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ATP Binding as a Key Target for Control of the Chemotaxis Kinase. Jun SY, et al. J Bacteriol, 2020 Jun 9. PMID 32341073, Free PMC Article
    2. Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states. Malik N, et al. Biochim Biophys Acta Biomembr, 2020 Sep 1. PMID 32304758, Free PMC Article
    3. Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes. Piñas GE, et al. J Bacteriol, 2019 Dec 1. PMID 31501279, Free PMC Article
    4. Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli. Gao Q, et al. Proc Natl Acad Sci U S A, 2019 Jul 30. PMID 31315979, Free PMC Article
    5. Regulatory Role of an Interdomain Linker in the Bacterial Chemotaxis Histidine Kinase CheA. Ding X, et al. J Bacteriol, 2018 May 15. PMID 29483161, Free PMC Article

    See all (156) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
      Title: Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
    2. ATP Binding as a Key Target for Control of the Chemotaxis Kinase.
      Title: ATP Binding as a Key Target for Control of the Chemotaxis Kinase.
    3. Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states.
      Title: Strategies for identifying dynamic regions in protein complexes: Flexibility changes accompany methylation in chemotaxis receptor signaling states.
    4. CheW truncated variants are able to drive chemotaxis behavior through activation and control of the CheA kinase. CheA control and networking activities reside in separate domains of CheW protein.
      Title: Truncated, Non-networking Versions of the Coupling Protein CheW Retain Chemoreceptor Control of Kinase CheA.
    5. It has been concluded that the dipped conformation of the CheA.P4 domain is critical to the kinase-active state in core signaling units.
      Title: Identification of a Kinase-Active CheA Conformation in Escherichia coli Chemoreceptor Signaling Complexes.
    6. Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli.
      Title: Conformational shifts in a chemoreceptor helical hairpin control kinase signaling in Escherichia coli.
    7. A model for signal transmission in chemotaxis signaling complexes in which the CheW-receptor interface plays the key role in conveying signaling-related conformational changes from receptors to the CheA kinase.
      Title: Noncritical Signaling Role of a Kinase-Receptor Interaction Surface in the Escherichia coli Chemosensory Core Complex.
    8. the interdomain linker is an active module that has the ability to impose regulatory effects on CheA activity
      Title: Regulatory Role of an Interdomain Linker in the Bacterial Chemotaxis Histidine Kinase CheA.
    9. Signaling complexes control CheA by altering its apparent rate constant of autophosphorylation.
      Title: Signaling complexes control the chemotaxis kinase by altering its apparent rate constant of autophosphorylation.
    10. Oxidized Aer activates CheA, whereas ASQ Aer reversibly inhibits CheA.
      Title: Bacterial Energy Sensor Aer Modulates the Activity of the Chemotaxis Kinase CheA Based on the Redox State of the Flavin Cofactor.
    Submit: New GeneRIF Correction See all GeneRIFs (24)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein histidine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in bacterial-type flagellum-dependent swimming motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemotaxis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of protein modification process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of post-translational protein modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of bacterial-type flagellum-dependent cell motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of chemotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of methyl accepting chemotaxis protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    chemotaxis protein CheA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1973360..1975324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_010283911.1 chemotaxis protein CheA [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

    2. NP_416402.2 chemotaxis protein CheA [Escherichia coli str. K-12 substr. MG1655]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A418GHL6
      Conserved Domains (1) summary
      PRK10547
      Location:1 → 557
      PRK10547; chemotaxis protein CheA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases
    Research Materials