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    Iyd iodotyrosine deiodinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308129, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Iydprovided by RGD
    Official Full Name
    iodotyrosine deiodinaseprovided by RGD
    Primary source
    RGD:1309288
    See related
    Ensembl:ENSRNOG00000016286 AllianceGenome:RGD:1309288
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309288
    Summary
    Predicted to enable FMN binding activity and iodotyrosine deiodinase activity. Predicted to be involved in thyroid hormone metabolic process and tyrosine metabolic process. Predicted to be located in cytoplasmic vesicle membrane; nucleoplasm; and plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Liver (RPKM 551.5) and Kidney (RPKM 446.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Iyd in Genome Data Viewer
    Location:
    1p11
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (42410099..42425414)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (40003999..40019323)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (40086513..40100966)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555832 Neighboring gene protein phosphatase 1, regulatory (inhibitor) subunit 14c Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene 60S ribosomal protein L7a pseudogene Neighboring gene cytochrome c, somatic like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Expression of Iodotyrosine Deiodinase in Thyroid and Other Organs in Iodine-Deficient and Iodine-Excess Rats. Sun X, et al. Biol Trace Elem Res, 2015 Oct. PMID 25850545
    2. A switch between one- and two-electron chemistry of the human flavoprotein iodotyrosine deiodinase is controlled by substrate. Hu J, et al. J Biol Chem, 2015 Jan 2. PMID 25395621, Free PMC Article
    3. Iodotyrosine dehalogenase 1 (DEHAL1) is a transmembrane protein involved in the recycling of iodide close to the thyroglobulin iodination site. Gnidehou S, et al. FASEB J, 2004 Oct. PMID 15289438
    4. Iodotyrosine deiodinase is the first mammalian member of the NADH oxidase/flavin reductase superfamily. Friedman JE, et al. J Biol Chem, 2006 Feb 3. PMID 16316988
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. iodine deficiency results in an increased expression of IYD in thyroid, whereas excess iodine decreases the expression of thyroidal IYD.
      Title: Expression of Iodotyrosine Deiodinase in Thyroid and Other Organs in Iodine-Deficient and Iodine-Excess Rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109018

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FMN binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables iodotyrosine deiodinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables iodotyrosine deiodinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in thyroid hormone metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thyroid hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in thyroid hormone metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in tyrosine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tyrosine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tyrosine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    iodotyrosine deiodinase 1
    Names
    IYD-1
    iodotyrosine dehalogenase 1
    NP_001020171.1
    XP_038966572.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025000.1 → NP_001020171.1  iodotyrosine deiodinase 1

      See identical proteins and their annotated locations for NP_001020171.1

      Status: PROVISIONAL

      Source sequence(s)
      BC091241
      UniProtKB/Swiss-Prot
      Q5BK17
      UniProtKB/TrEMBL
      A6KIK2
      Related
      ENSRNOP00000021893.4, ENSRNOT00000021895.8
      Conserved Domains (1) summary
      cd02144
      Location:89 → 281
      iodotyrosine_dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      42410099..42425414
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039110644.2 → XP_038966572.1  iodotyrosine deiodinase 1 isoform X1

      Conserved Domains (1) summary
      cl00514
      Location:89 → 174
      Nitro_FMN_reductase; nitroreductase family protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BK17.1 GenPept UniProtKB/Swiss-Prot:Q5BK17

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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