Scnn1g sodium channel epithelial 1 subunit gamma [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Scnn1gprovided by RGD
Official Full Name: sodium channel epithelial 1 subunit gammaprovided by RGD
Primary source: RGD:3641
See related: Ensembl:ENSRNOG00000017842 AllianceGenome:RGD:3641
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ENaC
Summary: Enables WW domain binding activity and ligand-gated sodium channel activity. Contributes to sodium ion transmembrane transporter activity. Involved in response to hypoxia; sodium ion transport; and wound healing, spreading of epidermal cells. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in Liddle syndrome; autosomal recessive pseudohypoaldosteronism type 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 136.5), Kidney (RPKM 108.1) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 1q36

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (185736225..185770099)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (176304942..176338816)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (191704397..191738271)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The SCNN1G defects triggered programmed cell death via inhibiting miR-21 and upregulating PTEN, which then orchestrated the key downstream regulators, including Bcl2, Bax2, and cleaved Caspse-3 in a way that favors cell apoptosis.
Title: A novel SCNN1G mutation in a PHA I infant patient correlates with nephropathy.
The presence of active plasmin in urine in hydronephrosis could cause abnormal proteolytic activation of ENaC-gamma and impaired ability to excrete Na via NCC.
Title: Hydronephrosis is associated with elevated plasmin in urine in pediatric patients and rats and changes in NCC and γ-ENaC abundance in rat kidney.
these findings reveal ENaC as an interactor and potential regulator of Cav3.2 calcium channels expressed in neuronal tissues.
Title: Cav3.2 calcium channel interactions with the epithelial sodium channel ENaC.
Based on the widespread presence of ENaC along the epididymis we suggest that mutations in ENaC subunits may also be associated with male infertility.
Title: Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.
gammaENaC may play an important role in the elevated myogenic response in Posterior Cerebral Arteries.
Title: Involvement of Epithelial Na(+) Channel in the Elevated Myogenic Response in Posterior Cerebral Arteries from Spontaneously Hypertensive Rats.
Decreased in plasma aldosterone, Na(+) and ENaC levels in kidneys under testosterone influence indicated that testosterone-induced increased in mean arterial pressure (MAP) were not due to increased plasma aldosterone and ENaC levels in kidneys, and thus the testosterone effect on MAP likely involve other mechanisms.
Title: Changes in plasma aldosterone and electrolytes levels, kidney epithelial sodium channel (ENaC) and blood pressure in normotensive WKY and hypertensive SHR rats following gonadectomy and chronic testosterone treatment.
Data suggest that dietary factors can regulate cardiac Scnn1g, Nedd4-2, and Sgk1 activity; here, proanthocyanidin dietary supplement PRO80 blocks aldosterone-dependent up-regulation of Scnn1g, Nedd4-2, and Sgk1 content in cardiac dysfunction. (Scnn1g = epithelial sodium channel 1, gamma subunit; Nedd4-2 = ubiquitin-protein ligase Nedd4-2; Sgk1 = serum-glucocorticoid regulated kinase 1)
Title: Proanthocyanidins block aldosterone-dependent up-regulation of cardiac gamma ENaC and Nedd4-2 inactivation via SGK1.
This study demonstrated that the formation of the heminodal Nav channel cluster adjacent to the presynaptic terminal occurs around hearing onset in the second week of postnatal age.
Title: Activity-dependent formation and location of voltage-gated sodium channel clusters at a CNS nerve terminal during postnatal development.
Kidneys respond acutely to hyperkalemic challenges by decreasing the activity of NCC while increasing that of ENaC.
Title: Responses of distal nephron Na(+) transporters to acute volume depletion and hyperkalemia.
deltabetagamma-ENaC is inhibited by CFTR but activated by cyclic AMP.
Title: δβγ-ENaC is inhibited by CFTR but stimulated by cAMP in Xenopus laevis oocytes.

Submit: New GeneRIF Correction See all GeneRIFs (72)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables WW domain binding	IEA Inferred from Electronic Annotation more info
enables WW domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables WW domain binding	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ligand-gated sodium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ligand-gated sodium channel activity	IEA Inferred from Electronic Annotation more info
contributes_to ligand-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligand-gated sodium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
contributes_to ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables ligand-gated sodium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to sodium channel activity	ISO Inferred from Sequence Orthology more info
contributes_to sodium ion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to acidic pH	IEA Inferred from Electronic Annotation more info
involved_in cellular response to acidic pH	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aldosterone	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to aldosterone	ISO Inferred from Sequence Orthology more info
involved_in cellular response to aldosterone	NAS Non-traceable Author Statement more info	PubMed
involved_in cellular response to vasopressin	NAS Non-traceable Author Statement more info	PubMed
involved_in intracellular sodium ion homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular sodium ion homeostasis	IEA Inferred from Electronic Annotation more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	IEA Inferred from Electronic Annotation more info
involved_in multicellular organismal-level water homeostasis	ISO Inferred from Sequence Orthology more info
involved_in multicellular organismal-level water homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of blood pressure	NAS Non-traceable Author Statement more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of salty taste	NAS Non-traceable Author Statement more info	PubMed
involved_in sensory perception of sour taste	NAS Non-traceable Author Statement more info	PubMed
involved_in sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in sodium ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of epidermal cells	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
part_of sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium channel complex	IEA Inferred from Electronic Annotation more info
part_of sodium channel complex	ISO Inferred from Sequence Orthology more info
part_of sodium channel complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: amiloride-sensitive sodium channel subunit gamma

Names: SCNEG; Sodium channel, nonvoltage-gated 1, gamma (epithelial); amiloride sensitive sodium channel gamma1 subunit; epithelial Na(+) channel subunit gamma; epithelial sodium channel gamma subunit; gamma-ENaC; gamma-NaCH; nonvoltage-gated sodium channel 1 subunit gamma; sodium channel epithelial 1 gamma subunit; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated, type I, gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017046.2 → NP_058742.2 amiloride-sensitive sodium channel subunit gamma

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P37091

UniProtKB/TrEMBL

A6I8V0, G3V8A6

Related

ENSRNOP00000024057.3, ENSRNOT00000024057.5

Conserved Domains (1) summary

TIGR00859
Location:24 → 631

ENaC; sodium channel transporter