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    Egfl8 EGF-like-domain, multiple 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 406166, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Egfl8provided by RGD
    Official Full Name
    EGF-like-domain, multiple 8provided by RGD
    Primary source
    RGD:1549706
    See related
    Ensembl:ENSRNOG00000000436 AllianceGenome:RGD:1549706
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ng3
    Summary
    Predicted to enable signaling receptor binding activity. Predicted to be involved in anatomical structure development. Predicted to act upstream of or within in utero embryonic development. Predicted to be active in cell surface and extracellular region. Orthologous to human EGFL8 (EGF like domain multiple 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 113.5), Thymus (RPKM 72.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Egfl8 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (4137531..4140632)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (4132930..4136024)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (4378205..4380959, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene FKBP prolyl isomerase like Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene proline-rich transmembrane protein 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene ring finger protein 5 Neighboring gene advanced glycosylation end product-specific receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Egfl7, a novel epidermal growth factor-domain gene expressed in endothelial cells. Fitch MJ, et al. Dev Dyn, 2004 Jun. PMID 15162510, Free PMC Article
    2. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC156528

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in anatomical structure development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    NOT involved_in in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT involved_in in utero embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in extracellular region IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor-like protein 8
    Names
    EGF-like domain 8
    EGF-like domain-containing protein 8
    EGF-like protein 8
    multiple EGF-like domain protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004070.3 → NP_001004070.1  epidermal growth factor-like protein 8 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001004070.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform.
      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A0A8I6AMC1, A6KTH4, A6KTH6
      Related
      ENSRNOP00000093713.1, ENSRNOT00000107302.1
      Conserved Domains (3) summary
      smart00179
      Location:143 → 170
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:36 → 100
      EMI; EMI domain
      cl00057
      Location:108 → 181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. NM_001165880.2 → NP_001159352.1  epidermal growth factor-like protein 8 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001159352.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' coding region compared to variant 1. The resulting protein (isoform 2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      A0A8I6AMC1, A6KTH4, A6KTH7
      Related
      ENSRNOP00000063796.2, ENSRNOT00000068712.5
      Conserved Domains (3) summary
      smart00179
      Location:143 → 170
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:36 → 100
      EMI; EMI domain
      cl00057
      Location:108 → 181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      4137531..4140632
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279354.1 → XP_063135424.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A6KTH6

    2. XM_063279353.1 → XP_063135423.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A6KTH6

    3. XM_039098934.2 → XP_038954862.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A0A8I6AMC1, A6KTH4, A6KTH6
      Related
      ENSRNOP00000000499.5
      Conserved Domains (3) summary
      smart00179
      Location:143 → 170
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:36 → 100
      EMI; EMI domain
      cl00057
      Location:108 → 181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    4. XM_006255978.5 → XP_006256040.1  epidermal growth factor-like protein 8 isoform X1

      See identical proteins and their annotated locations for XP_006256040.1

      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A0A8I6AMC1, A6KTH4, A6KTH6
      Conserved Domains (3) summary
      smart00179
      Location:143 → 170
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:36 → 100
      EMI; EMI domain
      cl00057
      Location:108 → 181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    5. XM_039098935.2 → XP_038954863.1  epidermal growth factor-like protein 8 isoform X1

      UniProtKB/Swiss-Prot
      A0JPK1, Q6MG84
      UniProtKB/TrEMBL
      A0A8I6AMC1, A6KTH4, A6KTH6
      Conserved Domains (3) summary
      smart00179
      Location:143 → 170
      EGF_CA; Calcium-binding EGF-like domain
      pfam07546
      Location:36 → 100
      EMI; EMI domain
      cl00057
      Location:108 → 181
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MG84.1 GenPept UniProtKB/Swiss-Prot:Q6MG84

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