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    Gfrl Glial cell line-derived neurotrophic family receptor-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346162, updated on 10-May-2024

    Summary

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    Official Symbol
    Gfrlprovided by FlyBase
    Official Full Name
    Glial cell line-derived neurotrophic family receptor-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0262869
    Locus tag
    Dmel_CG43224
    See related
    AllianceGenome:FB:FBgn0262869
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH26447; CG17203; CG17204; CG17205; CG17208; CG33518; CG34118; CG34119; CG42401; CG42625; CG42801; CG43224; CG4342; dGFRLA; dGFRLAb; Dmel\CG43224; DmGfrl; mun
    Old locus tag
    Dmel_CG17208; Dmel_CG33518; Dmel_CG34118; Dmel_CG34119; Dmel_CG42401; Dmel_CG42625; Dmel_CG42801; Dmel_CG4342
    Summary
    Enables cell adhesion molecule binding activity. Is anchored component of external side of plasma membrane. Is expressed in several structures, including adult central brain; early extended germ band embryo; embryonic/larval central nervous system; gut section; and presumptive embryonic/larval system. Orthologous to several human genes including GFRAL (GDNF family receptor alpha like). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gfrl in Genome Data Viewer
    Location:
    92E5-92E12; 3-68 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (20378458..20484588, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16204180..16310310, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45023 Neighboring gene Metallothionein C Neighboring gene eukaryotic translation initiation factor 3 subunit g2 Neighboring gene Trimethyllysine hydroxylase Neighboring gene long non-coding RNA:CR44400 Neighboring gene long non-coding RNA:CR44401

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional architecture of reward learning in mushroom body extrinsic neurons of larval Drosophila. Saumweber T, et al. Nat Commun, 2018 Mar 16. PMID 29549237, Free PMC Article
    2. The Genetic Basis of Natural Variation in Drosophila (Diptera: Drosophilidae) Virgin Egg Retention. Akhund-Zade J, et al. J Insect Sci, 2017 Jan. PMID 28042107, Free PMC Article
    3. A Catalog of GAL4 Drivers for Labeling and Manipulating Circadian Clock Neurons in Drosophila melanogaster. Sekiguchi M, et al. J Biol Rhythms, 2020 Apr. PMID 31856635
    4. The Drosophila Ret gene functions in the stomatogastric nervous system with the Maverick TGFβ ligand and the Gfrl co-receptor. Myers L, et al. Development, 2018 Feb 2. PMID 29361562, Free PMC Article
    5. Zebrafish GDNF and its co-receptor GFRα1 activate the human RET receptor and promote the survival of dopaminergic neurons in vitro. Saarenpää T, et al. PLoS One, 2017. PMID 28467503, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glial cell line-derived neurotrophic family receptor-like
    Names
    CG43224-PE
    CG43224-PF
    CG43224-PG
    CG43224-PH
    CG43224-PI
    CG43224-PJ
    CG43224-PK
    CG43224-PL
    CG43224-PM
    CG43224-PN
    GDNF Receptor-like
    Gfrl-PE
    Gfrl-PF
    Gfrl-PG
    Gfrl-PH
    Gfrl-PI
    Gfrl-PJ
    Gfrl-PK
    Gfrl-PL
    Gfrl-PM
    Gfrl-PN
    munin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      20378458..20484588 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300495.1 → NP_001287424.1  glial cell line-derived neurotrophic family receptor-like, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287424.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K785
      Conserved Domains (2) summary
      smart00907
      Location:574 → 660
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    2. NM_001260281.2 → NP_001247210.1  glial cell line-derived neurotrophic family receptor-like, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247210.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K785
      Conserved Domains (2) summary
      smart00907
      Location:574 → 660
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    3. NM_001260278.2 → NP_001247207.1  glial cell line-derived neurotrophic family receptor-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247207.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6R0
      Conserved Domains (2) summary
      smart00907
      Location:226 → 312
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    4. NM_001014642.5 → NP_001014642.4  glial cell line-derived neurotrophic family receptor-like, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014642.4

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59DV8
      Conserved Domains (2) summary
      smart00907
      Location:463 → 549
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    5. NM_001275827.2 → NP_001262756.1  glial cell line-derived neurotrophic family receptor-like, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KH06
      Conserved Domains (2) summary
      smart00907
      Location:574 → 660
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    6. NM_001260279.2 → NP_001247208.1  glial cell line-derived neurotrophic family receptor-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247208.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K785
      Conserved Domains (2) summary
      smart00907
      Location:574 → 660
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain

    7. NM_001260277.2 → NP_001247206.1  glial cell line-derived neurotrophic family receptor-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247206.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K7J4
      Conserved Domains (2) summary
      smart00907
      Location:641 → 727
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:94 → 173
      GDNF; GDNF/GAS1 domain

    8. NM_001300494.1 → NP_001287423.1  glial cell line-derived neurotrophic family receptor-like, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287423.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LIE3
      Conserved Domains (2) summary
      smart00907
      Location:404 → 490
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:94 → 173
      GDNF; GDNF/GAS1 domain

    9. NM_001260280.2 → NP_001247209.1  glial cell line-derived neurotrophic family receptor-like, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6A2
      Conserved Domains (2) summary
      smart00907
      Location:530 → 616
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:94 → 173
      GDNF; GDNF/GAS1 domain

    10. NM_001043267.3 → NP_001036732.1  glial cell line-derived neurotrophic family receptor-like, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IH40
      Conserved Domains (2) summary
      smart00907
      Location:126 → 203
      GDNF; GDNF/GAS1 domain
      pfam02351
      Location:27 → 106
      GDNF; GDNF/GAS1 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4K6A2 A0A0B4K6A2
    A0A0B4K6R0 A0A0B4K6R0
    A0A0B4K785 A0A0B4K785
    A0A0B4K7J4 A0A0B4K7J4
    A0A0B4KH06 A0A0B4KH06
    A0A0B4LIE3 A0A0B4LIE3
    Q59DV8 Q59DV8
    Q8IH40 Q8IH40
    Q8MQS5 Q8MQS5

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