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    Cyp9c1 Cytochrome P450 9c1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37941, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Cyp9c1provided by FlyBase
    Official Full Name
    Cytochrome P450 9c1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015040
    Locus tag
    Dmel_CG3616
    See related
    AllianceGenome:FB:FBgn0015040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    9c1; CG3616; Cyp9C1; CYP9C1; Dmel\CG3616; P-450; P450
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head. Human ortholog(s) of this gene implicated in several diseases, including Ghosal hematodiaphyseal syndrome; essential hypertension; familial Mediterranean fever; leukemia (multiple); and platelet-type bleeding disorder 14. Orthologous to several human genes including CYP3A4 (cytochrome P450 family 3 subfamily A member 4). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    60D10-60D10; 2-107 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24631063..24632923)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20518586..20520446)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aarF domain containing kinase 1 Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43787 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster. Sun W, et al. PLoS One, 2015. PMID 25761142, Free PMC Article
    2. Ran participates in deltamethrin stress through regulating the nuclear import of Nrf2. Ge M, et al. Gene, 2021 Feb 15. PMID 33069802
    3. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871
    4. Effects of the adenylate cyclase activator forskolin and its inactive derivative 1,9-dideoxyforskolin on insect cytochrome P-450 dependent steroid hydroxylase activity. Keogh DP, et al. Experientia, 1992 Jan 15. PMID 1737575
    5. [Ethanol inhibits recombination in somatic cells of gamma-irradiated larvae of Drosophila melanogaster]. Zakharenko LP, et al. Genetika, 1998 Mar. PMID 9589864

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transgenic flies, expressing the human ERRa-G allele, constitutively over-express Cyp12d1, Cyp6g2 and Cyp9c1.
      Title: A glycine insertion in the estrogen-related receptor (ERR) is associated with enhanced expression of three cytochrome P450 genes in transgenic Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 9c1
    Names
    CG3616-PA
    Cyp9c1-PA
    cytochrome P450-9c1
    NP_523850.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24631063..24632923
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079126.3 → NP_523850.1  cytochrome P450 9c1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523850.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24124, Q9W130
      Related
      FBpp0072228
      Conserved Domains (1) summary
      cl12078
      Location:37 → 514
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YND4 Q3YND4
    Q9W130.1 Q9W130

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