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    CG6891 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32865, updated on 4-Apr-2024

    Summary

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    Official Symbol
    CG6891provided by FlyBase
    Primary source
    FLYBASE:FBgn0030955
    Locus tag
    Dmel_CG6891
    See related
    AllianceGenome:FB:FBgn0030955
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Cotl1; Dmel\CG6891
    Summary
    Predicted to enable actin filament binding activity. Predicted to be involved in regulation of actin filament polymerization. Predicted to be active in cortical actin cytoskeleton and plasma membrane. Predicted to colocalize with actin filament. Is expressed in adult head; embryonic/larval muscle system; extended germ band embryo; visceral muscle primordium; and yolk nucleus. Orthologous to human COTL1 (coactosin like F-actin binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CG6891 in Genome Data Viewer
    Location:
    17D4-17D5; 1-60 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (18775228..18781345)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (18669261..18675378)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Cholecystokinin-like receptor at 17D3 Neighboring gene uncharacterized protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene S6 Kinase Like Neighboring gene Autophagy-related 101

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors. Pézeron G, et al. J Cell Sci, 2014 Nov 1. PMID 25217625, Free PMC Article
    2. Mammalian and Invertebrate Models as Complementary Tools for Gaining Mechanistic Insight on Muscle Responses to Spaceflight. Cahill T, et al. Int J Mol Sci, 2021 Aug 31. PMID 34502375, Free PMC Article
    3. Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover. Mastushita-Sakai T, et al. Proc Natl Acad Sci U S A, 2010 Jun 29. PMID 20547833, Free PMC Article
    4. Identification of conserved transcriptome features between humans and Drosophila in the aging brain utilizing machine learning on combined data from the NIH Sequence Read Archive. Webb JL, et al. PLoS One, 2021. PMID 34379632, Free PMC Article
    5. Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells. Jia D, et al. Dev Biol, 2022 Nov. PMID 36100084, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in site of polarized growth IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG6891-PA
    CG6891-PB
    CG6891-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      18775228..18781345
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_133095.2 → NP_573323.1  uncharacterized protein Dmel_CG6891, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_573323.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VWQ7
      Related
      FBpp0074402
      Conserved Domains (1) summary
      cd11282
      Location:28 → 139
      ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

    2. NM_001272760.1 → NP_001259689.1  uncharacterized protein Dmel_CG6891, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259689.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQX5
      Conserved Domains (1) summary
      cd11282
      Location:11 → 122
      ADF_coactosin_like; Coactosin-like members of the ADF homology domain family

    3. NM_167630.2 → NP_728196.1  uncharacterized protein Dmel_CG6891, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728196.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQX5
      Related
      FBpp0074403
      Conserved Domains (1) summary
      cd11282
      Location:11 → 122
      ADF_coactosin_like; Coactosin-like members of the ADF homology domain family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQX5 Q8IQX5
    Q8MQZ6 Q8MQZ6
    Q9VWQ7 Q9VWQ7

    Gene LinkOut

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