Pask PAS domain containing serine/threonine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Paskprovided by MGI
Official Full Name: PAS domain containing serine/threonine kinaseprovided by MGI
Primary source: MGI:MGI:2155936
See related: Ensembl:ENSMUSG00000026274 AllianceGenome:MGI:2155936
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA0135
Summary: Predicted to enable phosphatidylinositol binding activity and protein serine/threonine kinase activity. Involved in energy homeostasis; regulation of glucagon secretion; and regulation of respiratory gaseous exchange. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain ventricular layer; colon; liver; placenta; and spleen. Orthologous to human PASK (PAS domain containing serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 14.9), CNS E11.5 (RPKM 5.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 47.24 cM

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (93237165..93271237, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (93309437..93343522, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence.
Title: PASK links cellular energy metabolism with a mitotic self-renewal network to establish differentiation competence.
Adipose-Specific PPARalpha Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
Title: Adipose-Specific PPARα Knockout Mice Have Increased Lipogenesis by PASK-SREBP1 Signaling and a Polarity Shift to Inflammatory Macrophages in White Adipose Tissue.
Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
Title: Storage and Utilization of Glycogen by Mouse Liver during Adaptation to Nutritional Changes Are GLP-1 and PASK Dependent.
PAS kinase deficiency reduces aging effects in mice.
Title: PAS kinase deficiency reduces aging effects in mice.
Pask role in the liver metabolism during fasting.
Title: High-fat diet alters PAS kinase regulation by fasting and feeding in liver.
PASK regulated some of the genes and proteins responsible for glucose sensing, such as glucokinase.
Title: PAS Kinase deficiency alters the glucokinase function and hepatic metabolism.
The findings demonstrate cell-autonomous roles for PASK in the control of pancreatic endocrine hormone secretion. Differences between the glycaemic phenotype of global vs cell type-specific null mice suggest important roles for tissue interactions in the control of glycaemia by PASK.
Title: Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production.
the PAS kinase function could be critical for preserving the nutrient effect on AMP-activated protein kinase and mammalian target of rapamycin/S6K1 pathways and maintain the regulatory role of exendin-4 in food intake
Title: PAS kinase is a nutrient and energy sensor in hypothalamic areas required for the normal function of AMPK and mTOR/S6K1.
PASK is a key kinase in GLP-1 actions and exerts a coordinated response with the other metabolic sensors.
Title: PAS kinase as a nutrient sensor in neuroblastoma and hypothalamic cells required for the normal expression and activity of other cellular nutrient and energy sensors.
PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells.
Title: Per-Arnt-Sim kinase regulates pancreatic duodenal homeobox-1 protein stability via phosphorylation of glycogen synthase kinase 3β in pancreatic β-cells.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC193927P1 (e-PCR)
- UniSTS:271769

35.MMHAP65FRD11.seq (e-PCR)
- UniSTS:124152

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of glucagon secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory gaseous exchange	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular anatomical structure	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: PAS domain-containing serine/threonine-protein kinase

Names: PAS-kinase; paskin

NP_001408031.1

EC 2.7.11.1

NP_001408032.1

EC 2.7.11.1

NP_543126.2

EC 2.7.11.1

XP_006529730.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421102.1 → NP_001408031.1 PAS domain-containing serine/threonine-protein kinase

Status: VALIDATED

Source sequence(s)

AC124669

UniProtKB/Swiss-Prot

E9QM58, Q8CEE6, Q91YD8

UniProtKB/TrEMBL

B9EKC1
NM_001421103.1 → NP_001408032.1 PAS domain-containing serine/threonine-protein kinase

Status: VALIDATED

Source sequence(s)

AC124669

UniProtKB/Swiss-Prot

E9QM58, Q8CEE6, Q91YD8

UniProtKB/TrEMBL

B9EKC1
NM_080850.3 → NP_543126.2 PAS domain-containing serine/threonine-protein kinase

See identical proteins and their annotated locations for NP_543126.2

Status: VALIDATED

Source sequence(s)

AC124669

Consensus CDS

CCDS15186.1

UniProtKB/Swiss-Prot

E9QM58, Q8CEE6, Q91YD8

UniProtKB/TrEMBL

B9EKC1

Related

ENSMUSP00000027493.4, ENSMUST00000027493.4

Conserved Domains (3) summary

smart00091
Location:342 → 388

PAS; PAS domain

cd00130
Location:131 → 230

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd14004
Location:1058 → 1311

STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

93237165..93271237 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529667.2 → XP_006529730.1 PAS domain-containing serine/threonine-protein kinase isoform X1

See identical proteins and their annotated locations for XP_006529730.1

UniProtKB/Swiss-Prot

E9QM58, Q8CEE6, Q91YD8

UniProtKB/TrEMBL

B9EKC1

Conserved Domains (3) summary

smart00091
Location:342 → 388

PAS; PAS domain

cd00130
Location:131 → 230

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

cd14004
Location:1058 → 1311

STKc_PASK; Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase