S100a10 S100 calcium binding protein A10 (calpactin) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: S100a10provided by MGI
Official Full Name: S100 calcium binding protein A10 (calpactin)provided by MGI
Primary source: MGI:MGI:1339468
See related: Ensembl:ENSMUSG00000041959 AllianceGenome:MGI:1339468
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 42C; p10; p11; CAL12; CLP11; Cal1l
Summary: Predicted to enable several functions, including calcium-dependent protein binding activity; protein homodimerization activity; and transmembrane transporter binding activity. Acts upstream of or within positive regulation of binding activity. Is extrinsic component of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human S100A10 (S100 calcium binding protein A10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in large intestine adult (RPKM 148.7), placenta adult (RPKM 102.1) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.51 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (93462424..93471952)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (93555117..93564645)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
Title: Modulation of prostaglandin transport activity of SLCO2A1 by annexin A2 and S100A10.
S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice.
Title: S100a10 deficiency in neutrophils aggravates ulcerative colitis in mice.
Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.
Title: Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice.
Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Title: Essential roles of S100A10 in Toll-like receptor signaling and immunity to infection.
Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
Title: Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.
P11 is involved in regulating fibroblast cell proliferation and cell size. We observed anxiety-like disorder in addition to depression phenotype in the knockout mice.
Title: P11 Loss-of-Function is Associated with Decreased Cell Proliferation and Neurobehavioral Disorders in Mice.
Study reports that the transcription factor Sp1 controls p11 expression, which impacts on excitability by hampering functional expression of TASK1. In the SOD1-G93A mouse model of amyotrophic lateral sclerosis (ALS), Sp1-p11-TASK1 dysregulation contributes to increased excitability and vulnerability of motor neurons. Interference with either Sp1 or p11 delays neuron loss and prolongs lifespan in this model.
Title: Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.
p11KO male mice showed lower conditioned place preference than WT. In females there were no CPP differences between p11KO and WT.
Title: Knockout of p11 attenuates the acquisition and reinstatement of cocaine conditioned place preference in male but not in female mice.
p11 might be a potential regulator on 5-HTR1b and 5-HTR4 as well as a predictor of or a therapeutic target for IFN-alpha-induced depression.
Title: Probable involvement of p11 with interferon alpha induced depression.
data indicate that focal inhibition of p11 action in the dorsal striatum could be a promising PD therapeutic target to improve motor function while reducing l-dopa-induced dyskinesias
Title: Gene therapy blockade of dorsal striatal p11 improves motor function and dyskinesia in parkinsonian mice.

Submit: New GeneRIF Correction See all GeneRIFs (29)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125510 (e-PCR)
- UniSTS:162328

S100a10 (e-PCR), detects polymorphism
- UniSTS:480307

RH128467 (e-PCR)
- UniSTS:211775

S100a10 (e-PCR), detects polymorphism
- UniSTS:507204

S100a10 (e-PCR), detects polymorphism
- UniSTS:465493

M16465 (e-PCR)
- UniSTS:178878

RH124908 (e-PCR)
- UniSTS:161730

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to acid chemical	IDA Inferred from Direct Assay more info	PubMed
involved_in mRNA transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in membrane raft assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of GTPase activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of binding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exocytosis	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of plasma membrane repair	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of plasminogen activation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle budding from membrane	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of AnxA2-p11 complex	ISO Inferred from Sequence Orthology more info
part_of RNA polymerase II transcription regulator complex	IPI Inferred from Physical Interaction more info	PubMed
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with membrane raft	ISO Inferred from Sequence Orthology more info
located_in nuclear matrix	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of plasma membrane protein complex	EXP Inferred from Experiment more info	PubMed
part_of plasma membrane protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of plasma membrane protein complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein S100-A10

Names: S100 calcium binding protein A10 (calgizzarin); S100 calcium-binding protein A10; calcium binding protein A11 (calgizzarin); calpactin I light chain; calpactin-1 light chain; cellular ligand of annexin II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009112.2 → NP_033138.1 protein S100-A10

See identical proteins and their annotated locations for NP_033138.1

Status: VALIDATED

Source sequence(s)

AK161647, BU559648, D18288

Consensus CDS

CCDS38526.1

UniProtKB/Swiss-Prot

P08207

UniProtKB/TrEMBL

Q3TC45, Q3UF30

Related

ENSMUSP00000036949.8, ENSMUST00000045756.14

Conserved Domains (1) summary

cl08302
Location:3 → 93

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...