SIM1 SIM bHLH transcription factor 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: SIM1provided by CGNC
Full Name: SIM bHLH transcription factor 1provided by CGNC
Primary source: CGNC:49663
See related: Ensembl:ENSGALG00010015160
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	3	NC_052534.1 (70646809..70693397)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	3	NC_052575.1 (70421509..70468067)

Chromosome 3 - NC_052534.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sim1 gene expression is associated with the early step of muscle progenitor cell migration in chick and mouse, while the Sim2 gene is expressed just after the migration process
Title: Sim1 and Sim2 expression during chick and mouse limb development.

Submit: New GeneRIF Correction

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: single-minded homolog 1

Names: single-minded family bHLH transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

70646809..70693397

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040697741.2 → XP_040553675.1 single-minded homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8V0YT56

Conserved Domains (3) summary

cd00130
Location:118 → 188

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:273 → 359

PAS_3; PAS fold

cd19738
Location:1 → 71

bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
XM_004940356.5 → XP_004940413.1 single-minded homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8V0YT56, E1C5G3

Related

ENSGALP00010021284.1, ENSGALT00010036535.1

Conserved Domains (4) summary

cd00130
Location:88 → 158

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:243 → 329

PAS_3; PAS fold

cd19738
Location:1 → 71

bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins

pfam06621
Location:359 → 669

SIM_C; Single-minded protein C-terminus
XM_046939179.1 → XP_046795135.1 single-minded homolog 1 isoform X3

UniProtKB/TrEMBL

A0A8V0YT56
XM_004940357.5 → XP_004940414.1 single-minded homolog 1 isoform X4

UniProtKB/TrEMBL

A0A8V0YT56

Related

ENSGALP00010021280.1, ENSGALT00010036531.1

Conserved Domains (3) summary

cd00130
Location:1 → 57

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:142 → 228

PAS_3; PAS fold

pfam06621
Location:258 → 568

SIM_C; Single-minded protein C-terminus

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

70421509..70468067

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040666557.2 → XP_040522491.1 single-minded homolog 1 isoform X1

UniProtKB/TrEMBL

A0A8V0YT56

Conserved Domains (3) summary

cd00130
Location:118 → 188

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:273 → 359

PAS_3; PAS fold

cd19738
Location:1 → 71

bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
XM_040666559.2 → XP_040522493.1 single-minded homolog 1 isoform X2

UniProtKB/TrEMBL

A0A8V0YT56, E1C5G3

Conserved Domains (4) summary

cd00130
Location:88 → 158

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:243 → 329

PAS_3; PAS fold

cd19738
Location:1 → 71

bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins

pfam06621
Location:359 → 669

SIM_C; Single-minded protein C-terminus
XM_046914585.1 → XP_046770541.1 single-minded homolog 1 isoform X3

UniProtKB/TrEMBL

A0A8V0YT56
XM_040666560.2 → XP_040522494.1 single-minded homolog 1 isoform X4

UniProtKB/TrEMBL

A0A8V0YT56

Conserved Domains (3) summary

cd00130
Location:1 → 57

PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...

pfam08447
Location:142 → 228

PAS_3; PAS fold

pfam06621
Location:258 → 568

SIM_C; Single-minded protein C-terminus