U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Kcna6 potassium voltage-gated channel, shaker-related, subfamily, member 6 [ Mus musculus (house mouse) ]

    Gene ID: 16494, updated on 11-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Kcna6provided by MGI
    Official Full Name
    potassium voltage-gated channel, shaker-related, subfamily, member 6provided by MGI
    Primary source
    MGI:MGI:96663
    See related
    Ensembl:ENSMUSG00000038077 AllianceGenome:MGI:96663
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kv1.6; MK1.6
    Summary
    Predicted to enable delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to act upstream of or within ion transport and regulation of ion transmembrane transport. Located in axon terminus. Is expressed in several structures, including central nervous system; embryo mesenchyme; hindlimb muscle; neural retina; and trigeminal nerve. Orthologous to human KCNA6 (potassium voltage-gated channel subfamily A member 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in cerebellum adult (RPKM 9.9), cortex adult (RPKM 8.5) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Kcna6 in Genome Data Viewer
    Location:
    6 F3; 6 61.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (126685292..126717610, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (126708328..126740834, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33496 Neighboring gene potassium voltage-gated channel, shaker-related subfamily, member 1 Neighboring gene predicted gene, 33581 Neighboring gene predicted gene, 20190 Neighboring gene STARR-seq mESC enhancer starr_17397 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 pseudogene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Studying Independent Kcna6 Knock-out Mice Reveals Toxicity of Exogenous LacZ to Central Nociceptor Terminals and Differential Effects of Kv1.6 on Acute and Neuropathic Pain Sensation. Peck LJ, et al. J Neurosci, 2021 Nov 3. PMID 34544832, Free PMC Article
    2. Elevated potassium outward currents in hyperoxia treated atrial cardiomyocytes. Vysotskaya Z, et al. J Cell Physiol, 2018 May. PMID 29139549
    3. Seizures and reduced life span in mice lacking the potassium channel subunit Kv1.2, but hypoexcitability and enlarged Kv1 currents in auditory neurons. Brew HM, et al. J Neurophysiol, 2007 Sep. PMID 17634333
    4. Cloning, sequence and chromosomal localization of MK6, a murine potassium channel gene. Migeon MB, et al. Epilepsy Res Suppl, 1992. PMID 1285906
    5. Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. Petersson S, et al. Eur J Neurosci, 2003 Dec. PMID 14686897

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables delayed rectifier potassium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein homooligomerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon terminus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of monoatomic ion channel complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    potassium voltage-gated channel subfamily A member 6
    Names
    voltage-gated potassium channel subunit Kv1.6

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410072.1 → NP_001397001.1  potassium voltage-gated channel subfamily A member 6

      Status: VALIDATED

      Source sequence(s)
      AC079438, AC124756
      UniProtKB/Swiss-Prot
      Q61923

    2. NM_001410074.1 → NP_001397003.1  potassium voltage-gated channel subfamily A member 6

      Status: VALIDATED

      Source sequence(s)
      AC079438, AC124756
      UniProtKB/Swiss-Prot
      Q61923
      Related
      ENSMUSP00000107861.2, ENSMUST00000112242.2

    3. NM_001410075.1 → NP_001397004.1  potassium voltage-gated channel subfamily A member 6

      Status: VALIDATED

      Source sequence(s)
      AC079438, AC124756
      UniProtKB/Swiss-Prot
      Q61923

    4. NM_013568.7 → NP_038596.1  potassium voltage-gated channel subfamily A member 6

      See identical proteins and their annotated locations for NP_038596.1

      Status: VALIDATED

      Source sequence(s)
      AC079438, AC124756
      Consensus CDS
      CCDS20556.1
      UniProtKB/Swiss-Prot
      Q61923
      Related
      ENSMUSP00000036872.6, ENSMUST00000040751.6
      Conserved Domains (2) summary
      cd18407
      Location:41 → 170
      BTB_POZ_KCNA6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily A member 6 (KCNA6)
      pfam00520
      Location:258 → 468
      Ion_trans; Ion transport protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      126685292..126717610 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q61923.1 GenPept UniProtKB/Swiss-Prot:Q61923

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous