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    Arhgef15 Rho guanine nucleotide exchange factor 15 [ Mus musculus (house mouse) ]

    Gene ID: 442801, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Arhgef15provided by MGI
    Official Full Name
    Rho guanine nucleotide exchange factor 15provided by MGI
    Primary source
    MGI:MGI:3045246
    See related
    Ensembl:ENSMUSG00000052921 AllianceGenome:MGI:3045246
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    E5; D130071N09; D530030K12Rik
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in lung adult (RPKM 39.8), adrenal adult (RPKM 12.1) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arhgef15 in Genome Data Viewer
    Location:
    11 B3; 11 42.21 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68819726..68847760, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68928900..68956934, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22608 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene predicted gene, 51902 Neighboring gene STARR-positive B cell enhancer ABC_E8415 Neighboring gene predicted gene, 32273 Neighboring gene STARR-positive B cell enhancer ABC_E2994 Neighboring gene STARR-positive B cell enhancer ABC_E11482 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture. Ding X, et al. Acta Neuropathol, 2023 May. PMID 36929019
    2. ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice. Wang YJ, et al. Reprod Biol, 2023 Mar. PMID 36603298
    3. A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth. Hamilton AM, et al. Mol Cell Neurosci, 2017 Apr. PMID 28185854, Free PMC Article
    4. Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice. Sell GL, et al. J Clin Invest, 2017 May 1. PMID 28346227, Free PMC Article
    5. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. Kusuhara S, et al. PLoS One, 2012. PMID 23029280, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture.
      Title: Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture.
    2. ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice.
      Title: ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice.
    3. a substrate of PKCepsilon, Ephexin5, whose early-elevated expression in developing neurons may in part explain the mechanism by which PKCepsilon plays seemingly opposing roles that depend on neuronal maturity.
      Title: PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
    4. pathological elevation of Ephexin5 expression critically drives Abeta-induced memory impairment
      Title: Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.
    5. The data of this study support a model in which Ephexin5 serves a dual role in spinogenesis, acting both as a brake on overall spine outgrowth and as a necessary component in the site-specific formation of new spines
      Title: A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth.
    6. Study identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor triggers Ephexin5 phosphorylation, ubiquitination, and degradation.[Ephexin5]
      Title: EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC102247, MGC144141, MGC144142

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of postsynapse assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of postsynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 15
    Names
    Rho guanine nucleotide exchange factor (GEF) 15
    ephexin-5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001364772.2 → NP_001351701.1  rho guanine nucleotide exchange factor 15 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    2. NM_177566.5 → NP_808234.2  rho guanine nucleotide exchange factor 15 isoform 1

      See identical proteins and their annotated locations for NP_808234.2

      Status: VALIDATED

      Source sequence(s)
      AL603662
      Consensus CDS
      CCDS24873.1
      UniProtKB/Swiss-Prot
      Q14B44, Q5FWH6, Q69ZV7
      Related
      ENSMUSP00000067684.7, ENSMUST00000065040.13
      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      68819726..68847760 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249118.2 → XP_011247420.1  rho guanine nucleotide exchange factor 15 isoform X7

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    2. XM_011249122.2 → XP_011247424.1  rho guanine nucleotide exchange factor 15 isoform X12

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    3. XM_011249112.1 → XP_011247414.1  rho guanine nucleotide exchange factor 15 isoform X1

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    4. XM_011249117.1 → XP_011247419.1  rho guanine nucleotide exchange factor 15 isoform X6

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    5. XM_011249119.1 → XP_011247421.1  rho guanine nucleotide exchange factor 15 isoform X8

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    6. XM_030246113.1 → XP_030101973.1  rho guanine nucleotide exchange factor 15 isoform X2

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    7. XM_011249114.1 → XP_011247416.1  rho guanine nucleotide exchange factor 15 isoform X3

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    8. XM_011249121.1 → XP_011247423.1  rho guanine nucleotide exchange factor 15 isoform X10

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    9. XM_030246115.1 → XP_030101975.1  rho guanine nucleotide exchange factor 15 isoform X13

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630 → 691
      PH-like; Pleckstrin homology-like domain

    10. XM_030246114.1 → XP_030101974.1  rho guanine nucleotide exchange factor 15 isoform X11

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630 → 691
      PH-like; Pleckstrin homology-like domain

    11. XM_017314643.1 → XP_017170132.1  rho guanine nucleotide exchange factor 15 isoform X11

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630 → 691
      PH-like; Pleckstrin homology-like domain

    12. XM_006533664.2 → XP_006533727.1  rho guanine nucleotide exchange factor 15 isoform X5

      See identical proteins and their annotated locations for XP_006533727.1

      UniProtKB/Swiss-Prot
      Q14B44, Q5FWH6, Q69ZV7
      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    13. XM_011249120.1 → XP_011247422.1  rho guanine nucleotide exchange factor 15 isoform X9

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    14. XM_011249116.1 → XP_011247418.1  rho guanine nucleotide exchange factor 15 isoform X4

      See identical proteins and their annotated locations for XP_011247418.1

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    15. XM_011249115.1 → XP_011247417.1  rho guanine nucleotide exchange factor 15 isoform X4

      See identical proteins and their annotated locations for XP_011247417.1

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cd01221
      Location:630 → 750
      PH_ephexin; Ephexin Pleckstrin homology (PH) domain

    16. XM_006533669.2 → XP_006533732.1  rho guanine nucleotide exchange factor 15 isoform X14

      See identical proteins and their annotated locations for XP_006533732.1

      Conserved Domains (2) summary
      smart00325
      Location:430 → 606
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
      cl17171
      Location:630 → 691
      PH-like; Pleckstrin homology-like domain

    RNA

    1. XR_879714.4 RNA Sequence

    2. XR_001780023.1 RNA Sequence

    3. XR_388488.2 RNA Sequence

    4. XR_003949471.1 RNA Sequence

    5. XR_388487.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5FWH6.1 GenPept UniProtKB/Swiss-Prot:Q5FWH6

    Gene LinkOut

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