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    Adat1 Adenosine deaminase, tRNA-specific 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34787, updated on 26-Apr-2024

    Summary

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    Official Symbol
    Adat1provided by FlyBase
    Official Full Name
    Adenosine deaminase, tRNA-specific 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0028658
    Locus tag
    Dmel_CG16889
    See related
    AllianceGenome:FB:FBgn0028658
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adat; Adat; BG:DS00941.2; CG16889; dADAT1; Dmel\CG16889
    Summary
    Enables RNA binding activity and tRNA-specific adenosine deaminase activity. Involved in tRNA modification. Predicted to be active in cytoplasm and nucleolus. Is expressed in several structures, including germ layer; larval ventral nerve cord; and presumptive embryonic/larval central nervous system. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    34D1-34D1; 2-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13808360..13811474, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13808360..13811474, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Secretory 71 Neighboring gene Carbonic anhydrase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Son of sevenless

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification. Keegan LP, et al. Mol Cell Biol, 2000 Feb. PMID 10629039, Free PMC Article
    2. Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT. Catanese DJ Jr, et al. Biochem Biophys Res Commun, 2011 Oct 28. PMID 21971547, Free PMC Article
    3. A-to-I RNA editing: recent news and residual mysteries. Maas S, et al. J Biol Chem, 2003 Jan 17. PMID 12446659
    4. RNA editing by base deamination: more enzymes, more targets, new mysteries. Gerber AP, et al. Trends Biochem Sci, 2001 Jun. PMID 11406411
    5. Prediction and verification of microRNA targets by MovingTargets, a highly adaptable prediction method. Burgler C, et al. BMC Genomics, 2005 Jun 8. PMID 15943864, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DIP1-c was shown to interact with ADAT, a tRNA deaminase that presumably modifies pre-tRNAs.
      Title: Disconnected Interacting Protein 1 binds with high affinity to pre-tRNA and ADAT.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables adenosine deaminase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables double-stranded RNA adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables double-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-specific adenosine deaminase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in adenosine to inosine editing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenosine deaminase, tRNA-specific 1
    Names
    Adat1-PA
    Adat1-PB
    CG16889-PA
    CG16889-PB
    adat
    NP_001260450.1
    NP_609676.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13808360..13811474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135832.3 → NP_609676.1  adenosine deaminase, tRNA-specific 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609676.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3R6
      UniProtKB/TrEMBL
      M9PDF5, N0BSY1
      Related
      FBpp0080150
      Conserved Domains (1) summary
      smart00552
      Location:7 → 389
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)

    2. NM_001273521.1 → NP_001260450.1  adenosine deaminase, tRNA-specific 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3R6
      UniProtKB/TrEMBL
      M9PDF5, N0BSY1
      Conserved Domains (1) summary
      smart00552
      Location:7 → 389
      ADEAMc; tRNA-specific and double-stranded RNA adenosine deaminase (RNA-specific editase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDF5 M9PDF5
    Q9V3R6.1 Q9V3R6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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