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    espJ ESX-1 secretion-associated protein EspJ [ Mycobacterium tuberculosis H37Rv ]

    Gene ID: 886198, updated on 6-Jun-2024

    Summary

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    Gene symbol
    espJ
    Gene description
    ESX-1 secretion-associated protein EspJ
    Locus tag
    Rv3878
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mycobacterium tuberculosis H37Rv (strain: H37Rv, type-material: type strain of Mycobacterium tuberculosis)
    Lineage
    Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex
    Also known as
    TB27.4
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    Genomic context

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    Sequence:
    NC_000962.3 (4356693..4357535)

    NC_000962.3Genomic Context describing neighboring genes Neighboring gene ESAT-6 protein EsxA Neighboring gene ESX-1 secretion-associated protein EspI Neighboring gene ESX-1 secretion system protein EccD1 Neighboring gene ESX-1 secretion-associated protein EspK Neighboring gene ESX-1 secretion-associated protein EspL Neighboring gene ESX-1 secretion-associated protein EspB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000962.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria. Singh PK, et al. Sci Rep, 2015 Jul 31. PMID 26228622, Free PMC Article
    2. Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms. Jiang Y, et al. Tuberculosis (Edinb), 2014 May. PMID 24674998
    3. [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection]. Liu XQ. Zhongguo Yi Xue Ke Xue Yuan Xue Bao, 2008 Jun. PMID 18686610
    4. Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. Abdallah AM, et al. PLoS One, 2019. PMID 30673778, Free PMC Article
    5. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. McLaughlin B, et al. PLoS Pathog, 2007 Aug 3. PMID 17676952, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these data show that WhiB6 is required for the secretion-dependent regulation of ESX-1 substrates and that ESX-1 substrates are regulated independently from the structural components, both during infection and as a result of active secretion.
      Title: Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator.
    2. EspJ protein gets phosph.orylated prior to affect the growth and intracellular survival of Mycobacterium tuberculosis.
      Title: RD-1 encoded EspJ protein gets phosphorylated prior to affect the growth and intracellular survival of mycobacteria.
    3. The results show that Rv3878 is conserved in M Tuberc and contains polymorphisms which may reflect ongoing immune evasion
      Title: Conserved alanine rich protein Rv3878 in Mycobacterium tuberculosis contains sequence polymorphisms.
    4. The T cell response rates to Rv3873, Rv3878, and Rv3879c were 53% (95% CI: 39%-67%), 35% (95% CI: 22%-48%), and 45% (95% CI: 31%-57%), respectively, in the TB group and were 7.9%, 2.6%, and 2.6%, respectively, in the control group.
      Title: [Application of T cell responses to novel RD1-encoded mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection].
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    ESX-1 secretion-associated protein EspJ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000962.3 Reference assembly

      Range
      4356693..4357535
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_218395.1 ESX-1 secretion-associated protein EspJ [Mycobacterium tuberculosis H37Rv]

      See identical proteins and their annotated locations for NP_218395.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0AAC8V6K0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P9WJC3.1

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