U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dmtn dematin actin binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361069, updated on 25-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dmtnprovided by RGD
    Official Full Name
    dematin actin binding proteinprovided by RGD
    Primary source
    RGD:1311419
    See related
    Ensembl:ENSRNOG00000012273 AllianceGenome:RGD:1311419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Epb49; Epb4.9
    Summary
    Predicted to enable cytoskeletal protein binding activity; protein self-association; and signaling receptor binding activity. Predicted to be involved in several processes, including calcium-mediated signaling; negative regulation of protein phosphorylation; and regulation of cell-substrate adhesion. Predicted to be located in several cellular components, including cytoskeleton; platelet dense tubular network membrane; and postsynaptic density. Predicted to be active in actin cytoskeleton and plasma membrane. Orthologous to human DMTN (dematin actin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 220.0), Brain (RPKM 165.5) and 5 other tissues See more
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Dmtn in Genome Data Viewer
    Location:
    15p11
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (52087667..52111956, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (45677974..45702261, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (52292762..52320385, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 18 Neighboring gene FHF complex subunit HOOK interacting protein 2B Neighboring gene fibroblast growth factor 17 Neighboring gene nucleophosmin/nucleoplasmin 2 Neighboring gene uncharacterized LOC134482146

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). Chen L, et al. J Biol Chem, 2013 Mar 22. PMID 23355471, Free PMC Article
    2. Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction. Koshino I, et al. J Biol Chem, 2012 Oct 12. PMID 22927433, Free PMC Article
    3. Dematin exhibits a natively unfolded core domain and an independently folded headpiece domain. Chen L, et al. Protein Sci, 2009 Mar. PMID 19241372, Free PMC Article
    4. Loss of heterozygosity on 8p in prostate cancer implicates a role for dematin in tumor progression. Lutchman M, et al. Cancer Genet Cytogenet, 1999 Nov. PMID 10565303
    5. The headpiece domain of dematin regulates cell shape, motility, and wound healing by modulating RhoA activation. Mohseni M, et al. Mol Cell Biol, 2008 Aug. PMID 18505823, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables spectrin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin filament bundle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin filament bundle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to cAMP ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to calcium ion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lamellipodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-threonine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein targeting to membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of blood coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin filament ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell projection membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cortical cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in platelet dense tubular network membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spectrin-associated cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dematin
    Names
    erythrocyte membrane protein band 4.9 (dematin)
    erythrocyte protein band 4.9

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394746.1 → NP_001381675.1  dematin isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      Conserved Domains (2) summary
      smart00153
      Location:370 → 405
      VHP; Villin headpiece domain
      pfam16182
      Location:8 → 369
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    2. NM_001394747.1 → NP_001381676.1  dematin isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6HTM3, D4A559
      Related
      ENSRNOP00000097697.1, ENSRNOT00000106565.1
      Conserved Domains (2) summary
      smart00153
      Location:348 → 383
      VHP; Villin headpiece domain
      pfam16182
      Location:8 → 347
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    3. NM_001394748.1 → NP_001381677.1  dematin isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A0A8I5ZXT2
      Related
      ENSRNOP00000084709.1, ENSRNOT00000097002.1
      Conserved Domains (2) summary
      smart00153
      Location:345 → 380
      VHP; Villin headpiece domain
      pfam16182
      Location:7 → 344
      AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      52087667..52111956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108385.1: Suppressed sequence

      Description
      NM_001108385.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools