CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CAMK2N1provided by HGNC
Official Full Name: calcium/calmodulin dependent protein kinase II inhibitor 1provided by HGNC
Primary source: HGNC:HGNC:24190
See related: Ensembl:ENSG00000162545 MIM:614986; AllianceGenome:HGNC:24190
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRO1489
Summary: Enables calcium-dependent protein kinase inhibitor activity and protein kinase binding activity. Involved in several processes, including negative regulation of ERK1 and ERK2 cascade; negative regulation of cell population proliferation; and negative regulation of cellular protein metabolic process. Predicted to be located in synapse. Implicated in ovarian cancer; ovarian carcinoma; and prostate adenocarcinoma. Biomarker of hepatocellular carcinoma; oral squamous cell carcinoma; prostate cancer; and thyroid gland papillary carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in brain (RPKM 113.3), colon (RPKM 48.8) and 15 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.12

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (20482391..20486210, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (20307345..20311164, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (20808884..20812703, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/beta-catenin pathway.
Title: CAMK2N1 has a cancer-suppressive function in colorectal carcinoma via effects on the Wnt/β-catenin pathway.
CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling.
Title: CAMK2N1 suppresses hepatoma growth through inhibiting E2F1-mediated cell-cycle signaling.
MiR-129-5p promotes docetaxel resistance in prostate cancer by down-regulating CAMK2N1 expression.
Title: MiR-129-5p promotes docetaxel resistance in prostate cancer by down-regulating CAMK2N1 expression.
Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.
Title: Breakage of the oligomeric CaMKII hub by the regulatory segment of the kinase.
miR-532 promotes cell proliferation and invasion in t(4;14) MMs by targeting CAMK2N1.
Title: MicroRNA-532 exerts oncogenic functions in t(4;14) multiple myeloma by targeting CAMK2N1.
CAMK2N1 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.
Hypermethylation of RUNX3/CAMK2N1 is associated with poor clinical outcome in Type II EOC, also after macroscopic complete resection.
Title: RUNX3 and CAMK2N1 hypermethylation as prognostic marker for epithelial ovarian cancer.
contributes to prostate cancer growth and survival through androgen receptor-dependent signaling
Title: CAMK2N1 inhibits prostate cancer progression through androgen receptor-dependent signaling.
Analyses suggest that CAMK2N1 plays a tumor suppressive role in prostate cancer cells. Reduced CAMK2N1 expression correlates to human prostate cancer progression and predicts poor clinical outcome.
Title: The tumor suppressive role of CAMK2N1 in castration-resistant prostate cancer.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-35895 (e-PCR)
- UniSTS:74120

SHGC-74338 (e-PCR)
- UniSTS:77450

SHGC-74339 (e-PCR)
- UniSTS:42411

SHGC-74356 (e-PCR)
- UniSTS:31150

HSC1IC062 (e-PCR)
- UniSTS:39120

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables calcium-dependent protein kinase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in long-term memory	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IEA Inferred from Electronic Annotation more info
located_in synapse	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: calcium/calmodulin-dependent protein kinase II inhibitor 1

Names: CaMKIINalpha; caMKII inhibitory protein alpha; caMKIIN-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.