Cend1 cell cycle exit and neuronal differentiation 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cend1provided by MGI
Official Full Name: cell cycle exit and neuronal differentiation 1provided by MGI
Primary source: MGI:MGI:1929898
See related: Ensembl:ENSMUSG00000060240 AllianceGenome:MGI:1929898
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BM88; 1500001H12Rik
Summary: Involved in neuron differentiation. Acts upstream of or within adult walking behavior; hindbrain development; and negative regulation of cerebellar granule cell precursor proliferation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to colocalize with mitochondrion and vesicle. Is expressed in central nervous system; peripheral nervous system ganglion; sensory organ; and urethra. Orthologous to human CEND1 (cell cycle exit and neuronal differentiation 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 92.4), cortex adult (RPKM 51.6) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 86.77 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141006359..141009475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (141426446..141429562, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.
Title: CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.
data suggest that common reprogramming mechanisms exist driving the conversion of lineage-distant somatic cell types to neurons and reveal a critical role for CEND1 in NEUROG2-driven astrocytic reprogramming.
Title: CEND1 and NEUROGENIN2 Reprogram Mouse Astrocytes and Embryonic Fibroblasts to Induced Neural Precursors and Differentiated Neurons.
results suggest that functional interactions between BM88/Cend1, RanBPM and Dyrk1B affect the balance between cellular proliferation and differentiation in Neuro 2a cells
Title: Functional Interactions between BM88/Cend1, Ran-binding protein M and Dyrk1B kinase affect cyclin D1 levels and cell cycle progression/exit in mouse neuroblastoma cells.
This study suggested that Cend1 is involved in Ahi1-associated hypothalamic neuronal differentiation in early development, giving us fresh insight into the mechanism behind the delayed development in Joubert syndrome.
Title: Loss of Ahi1 affects early development by impairing BM88/Cend1-mediated neuronal differentiation.
Our results suggest that Cend1 is required for normal cerebellar development.
Title: Impaired cerebellar development and deficits in motor coordination in mice lacking the neuronal protein BM88/Cend1.
Transplantation of BM88/Cend1-overexpressing neural progenitor cells exerts beneficial effects on tissue regeneration by enhancing the number of generated neurons and restricting the formation of astroglial scar, in a mouse model of cortical brain injury.
Title: Transplantation of embryonic neural stem/precursor cells overexpressing BM88/Cend1 enhances the generation of neuronal cells in the injured mouse cortex.
BM88/Cend1 participates in cell cycle control and neuronal differentiation mechanisms during neonatal SVZ neurogenesis and becomes crucial for the transition from neuroblasts to mature neurons when reaching high levels
Title: BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells.
Results implicate BM88 in the synchronization of cell cycle exit and differentiation of neuronal precursors in the developing nervous system.
Title: BM88/CEND1 coordinates cell cycle exit and differentiation of neuronal precursors.
BM88 is widely expressed in the embryonic CNS and PNS, in both nestin-positive neuroepithelial cells and post-mitotic betaIII-tubulin positive neurons.
Title: Expression pattern of BM88 in the developing nervous system of the chick and mouse embryo.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235811

Cend1 (e-PCR), detects polymorphism
- UniSTS:531330

AI415214 (e-PCR)
- UniSTS:185743

AI060884 (e-PCR)
- UniSTS:159720

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within adult walking behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cerebellar Purkinje cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellar Purkinje cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellar granular layer maturation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cerebellar granular layer maturation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cerebellum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cerebellar granule cell precursor proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in radial glia guided migration of cerebellar granule cell	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within radial glia guided migration of cerebellar granule cell	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
colocalizes_with mitochondrion	ISO Inferred from Sequence Orthology more info
colocalizes_with vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell cycle exit and neuronal differentiation protein 1

Names: BM88 antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001360485.1 → NP_001347414.1 cell cycle exit and neuronal differentiation protein 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC158224, AC163434

Consensus CDS

CCDS22012.1

UniProtKB/Swiss-Prot

Q9DBA0, Q9JKC6

Related

ENSMUSP00000123334.2, ENSMUST00000137488.2

Conserved Domains (1) summary

pfam15677
Location:1 → 149

CEND1; Cell cycle exit and neuronal differentiation protein 1
NM_021316.5 → NP_067291.1 cell cycle exit and neuronal differentiation protein 1

See identical proteins and their annotated locations for NP_067291.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.

Source sequence(s)

AC158224, AC163434, AK079045

Consensus CDS

CCDS22012.1

UniProtKB/Swiss-Prot

Q9DBA0, Q9JKC6

Related

ENSMUSP00000118591.2, ENSMUST00000124444.2

Conserved Domains (1) summary

pfam15677
Location:1 → 149

CEND1; Cell cycle exit and neuronal differentiation protein 1