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    Cyp3a25 cytochrome P450, family 3, subfamily a, polypeptide 25 [ Mus musculus (house mouse) ]

    Gene ID: 56388, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Cyp3a25provided by MGI
    Official Full Name
    cytochrome P450, family 3, subfamily a, polypeptide 25provided by MGI
    Primary source
    MGI:MGI:1930638
    See related
    Ensembl:ENSMUSG00000029630 AllianceGenome:MGI:1930638
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable several functions, including caffeine oxidase activity; iron ion binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in cytoplasm. Is expressed in liver and lung. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; essential hypertension; and familial Mediterranean fever. Orthologous to human CYP3A4 (cytochrome P450 family 3 subfamily A member 4); CYP3A43 (cytochrome P450 family 3 subfamily A member 43); and CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in liver adult (RPKM 60.0), liver E18 (RPKM 11.2) and 3 other tissues See more
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    Genomic context

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    Location:
    5 G2; 5 85.17 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (145914002..145946454, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (145977192..146009644, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38744 Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 11 Neighboring gene STARR-seq mESC enhancer starr_14836 Neighboring gene STARR-seq mESC enhancer starr_14837 Neighboring gene STARR-seq mESC enhancer starr_14838 Neighboring gene predicted gene 8454 Neighboring gene STARR-seq mESC enhancer starr_14839 Neighboring gene NSA2 ribosome biogenesis homolog pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase. Dai D, et al. J Biochem Mol Toxicol, 2001. PMID 11284050
    2. A map of the mouse Cyp3a locus. Zaphiropoulos PG. DNA Seq, 2003 Jun. PMID 14509827
    3. Zinc Fingers and Homeoboxes 2 (Zhx2) Regulates Sexually Dimorphic Cyp Gene Expression in the Adult Mouse Liver. Creasy KT, et al. Gene Expr, 2016. PMID 27197076, Free PMC Article
    4. Comparative expression profiling of 40 mouse cytochrome P450 genes in embryonic and adult tissues. Choudhary D, et al. Arch Biochem Biophys, 2003 Jun 1. PMID 12745259
    5. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aromatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables estrogen 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables estrogen 2-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables retinoic acid 4-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables steroid hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 16-alpha-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables testosterone 6-beta-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in oxidative demethylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 3A25
    Names
    CYPIIIA25
    cytochrome P450, 3a25
    NP_062766.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019792.2 → NP_062766.2  cytochrome P450 3A25

      See identical proteins and their annotated locations for NP_062766.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes a functional protein.
      Source sequence(s)
      AK149541, BY099368, Y11995
      Consensus CDS
      CCDS19866.1
      UniProtKB/Swiss-Prot
      O09158
      UniProtKB/TrEMBL
      Q9QXK4
      Related
      ENSMUSP00000065585.7, ENSMUST00000068317.13
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 493
      p450; Cytochrome P450

    RNA

    1. NR_030782.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the CDS, as compared to variant 1. The resulting transcript is a nonsense-mediated mRNA decay candidate, and is probably not making a protein.
      Source sequence(s)
      AK149541
      Related
      ENSMUST00000145062.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      145914002..145946454 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_003955679.1 RNA Sequence

    2. XR_003955678.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O09158.1 GenPept UniProtKB/Swiss-Prot:O09158

    Gene LinkOut

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