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    Myl1 myosin, light polypeptide 1 [ Mus musculus (house mouse) ]

    Gene ID: 17901, updated on 21-Apr-2024

    Summary

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    Official Symbol
    Myl1provided by MGI
    Official Full Name
    myosin, light polypeptide 1provided by MGI
    Primary source
    MGI:MGI:97269
    See related
    Ensembl:ENSMUSG00000061816 AllianceGenome:MGI:97269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mylf; MLC1f; MLC3f
    Summary
    Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two non-phosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in fast skeletal muscle. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in mammary gland adult (RPKM 118.5), limb E14.5 (RPKM 25.3) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C3; 1 33.71 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (66963454..66987091, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (66924295..66947932, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene acyl-Coenzyme A dehydrogenase, long-chain Neighboring gene predicted gene, 27934 Neighboring gene predicted gene, 25832 Neighboring gene STARR-seq mESC enhancer starr_01192 Neighboring gene ribosomal protein L31, pseudogene 14 Neighboring gene histidyl-tRNA synthetase pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inducible activation of Akt increases skeletal muscle mass and force without satellite cell activation. Blaauw B, et al. FASEB J, 2009 Nov. PMID 19661286
    2. Regulation of cell proliferation by fast Myosin light chain 1 in myoblasts derived from extraocular muscle, diaphragm and gastrocnemius. Zhang SZ, et al. Exp Biol Med (Maywood), 2008 Nov. PMID 18957633
    3. Selective expression of Cre recombinase in skeletal muscle fibers. Bothe GW, et al. Genesis, 2000 Feb. PMID 10686620
    4. Embryonic and fetal myogenic programs act through separate enhancers at the MLC1F/3F locus. Kelly RG, et al. Dev Biol, 1997 Jul 15. PMID 9242416
    5. Distinct regulatory elements control muscle-specific, fiber-type-selective, and axially graded expression of a myosin light-chain gene in transgenic mice. Rao MV, et al. Mol Cell Biol, 1996 Jul. PMID 8668209, Free PMC Article

    See all (178) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. aPKCzeta is required for the cellular organization of acto-non-muscle myosin II (NMII) cytoskeleton, for proper cell adhesion and directed cell migration.
      Title: aPKCζ affects directed cell migration through the regulation of myosin light chain phosphorylation.
    2. This study provides an additional mechanistic link between Angiotensin II and vasoconstriction via SFK-enhanced MLC phosphorylation in smooth muscle cells.
      Title: Src Family Kinases (SFK) Mediate Angiotensin II-Induced Myosin Light Chain Phosphorylation and Hypertension.
    3. Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46.
      Title: L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
    4. Results show that the binding force between selenium and cardiac myosin (CM), which consists of two heavy chains (MHC) and two pairs of light chains: MLC1 and MLC2, was 100 times stronger than that of daunorubicin (DNR) and CM.
      Title: Effect of selenium on the interaction between daunorubicin and cardiac myosin.
    5. The present work further established the role of MuRF1 in muscle atrophy and for the first time shows that MuRF1 plays a role in muscle fatigue and twitch potentiation.
      Title: Modulation of muscle atrophy, fatigue and MLC phosphorylation by MuRF1 as indicated by hindlimb suspension studies on MuRF1-KO mice.
    6. MLC1f expression is reversely related to the proliferation of muscle cells.
      Title: Regulation of cell proliferation by fast Myosin light chain 1 in myoblasts derived from extraocular muscle, diaphragm and gastrocnemius.
    7. Using double reporter transgenes study demonstrates that each enhancer can activate both Mlc1f and Mlc3f promoters in vivo, revealing enhancer sharing rather than exclusive enhancer-promoter interactions.
      Title: Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus.
    8. Targeted deletion of the MLC1f/3 downstream enhancer results in precocious MLC expression and mesoderm ablation. This suggests that the enhancer and its flanking sequences in clude negative regulatory elements as well as positive ones.
      Title: Targeted deletion of the MLC1f/3f downstream enhancer results in precocious MLC expression and mesoderm ablation.
    9. myotome pairs are transiently left-right asymmetric, with higher expression of alpha-skeletal actin and myosin light chain 3F (MLC3F) on the left side between embryonic day 9.5-10.25.
      Title: Mouse myotomes pairs exhibit left-right asymmetric expression of MLC3F and alpha-skeletal actin.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (4)  1 citation
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of muscle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in contractile muscle fiber IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in contractile muscle fiber ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in myofibril ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of myosin II complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin light chain 1/3, skeletal muscle isoform
    Names
    A1 catalytic
    A2 catalytic
    MLC1/MLC3
    MLC1F/MLC3F
    myosin light chain A1/A2
    myosin light chain alkali 1/2
    myosin light chain, alkali, fast skeletal muscle
    myosin, light polypeptide 1, alkali; atrial, embryonic
    myosin, light polypeptide 4, alkali; atrial, embryonic

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113387.2 → NP_001106858.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      See identical proteins and their annotated locations for NP_001106858.1

      Status: VALIDATED

      Source sequence(s)
      AC124389
      Consensus CDS
      CCDS48284.1
      UniProtKB/TrEMBL
      Q545G5, Q6PCW9
      Related
      ENSMUSP00000112861.2, ENSMUST00000119429.8
      Conserved Domains (1) summary
      PTZ00184
      Location:4 → 149
      PTZ00184; calmodulin; Provisional

    2. NM_001420333.1 → NP_001407262.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      Status: VALIDATED

      Source sequence(s)
      AC124389, AC133187
      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7

    3. NM_001420334.1 → NP_001407263.1  myosin light chain 1/3, skeletal muscle isoform isoform 3f

      Status: VALIDATED

      Source sequence(s)
      AC124389
      UniProtKB/TrEMBL
      Q545G5

    4. NM_021285.4 → NP_067260.1  myosin light chain 1/3, skeletal muscle isoform isoform 1f

      See identical proteins and their annotated locations for NP_067260.1

      Status: VALIDATED

      Source sequence(s)
      AC124389, AC133187
      Consensus CDS
      CCDS15024.1
      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Related
      ENSMUSP00000027151.6, ENSMUST00000027151.12
      Conserved Domains (1) summary
      PTZ00184
      Location:39 → 187
      PTZ00184; calmodulin; Provisional

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      66963454..66987091 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162616.1 → XP_036018509.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Conserved Domains (1) summary
      PTZ00184
      Location:39 → 187
      PTZ00184; calmodulin; Provisional

    2. XM_036162618.1 → XP_036018511.1  myosin light chain 1/3, skeletal muscle isoform isoform X1

      UniProtKB/Swiss-Prot
      P05977, P05978
      UniProtKB/TrEMBL
      Q545T7
      Conserved Domains (1) summary
      PTZ00184
      Location:39 → 187
      PTZ00184; calmodulin; Provisional

    3. XM_011238451.4 → XP_011236753.1  myosin light chain 1/3, skeletal muscle isoform isoform X2

      UniProtKB/TrEMBL
      E9PWG4, Q6PCW9
      Related
      ENSMUSP00000112880.2, ENSMUST00000120415.8
      Conserved Domains (1) summary
      PTZ00184
      Location:4 → 141
      PTZ00184; calmodulin; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05977.2 GenPept UniProtKB/Swiss-Prot:P05977

    Gene LinkOut

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