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    JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough [ Homo sapiens (human) ]

    Gene ID: 8681, updated on 5-Mar-2024

    Summary

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    Official Symbol
    JMJD7-PLA2G4Bprovided by HGNC
    Official Full Name
    JMJD7-PLA2G4B readthroughprovided by HGNC
    Primary source
    HGNC:HGNC:34449
    See related
    Ensembl:ENSG00000168970 AllianceGenome:HGNC:34449
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HsT16992; cPLA2-beta
    Summary
    This locus represents naturally-occurring readthrough transcription between the neighboring jumonji domain containing 7 (JMJD7) and phospholipase A2, group IVB (cytosolic) (PLA2G4B) genes. Readthrough transcripts encode fusion proteins that share amino acid sequence with each individual gene product, including a partial JmjC domain and downstream C2 and phospholipase A2 domains. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Oct 2013]
    Annotation information
    Note: This geneID was previously used to represent the PLA2G4B locus; however, it is now believed that this gene represents a set of read-through transcripts from the upstream JmjC-domain containing gene (geneID: 100137047) into the separate PLA2G4B gene. Consequently, PLA2G4B is now represented by geneID:100137049. [13 Feb 2013]
    Expression
    Ubiquitous expression in skin (RPKM 27.8), esophagus (RPKM 12.4) and 24 other tissues See more
    Orthologs
    all
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    Genomic context

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    Location:
    15q15.1
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41828092..41848143)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39634005..39654098)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (42120290..42140341)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9285 Neighboring gene mitogen-activated protein kinase binding protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:42117960-42118842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9286 Neighboring gene Sharpr-MPRA regulatory region 5929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42144871-42145480 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42145481-42146091 Neighboring gene jumonji domain containing 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42147073-42147589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42147590-42148105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:42148623-42149137 Neighboring gene phospholipase A2 group IVB Neighboring gene RNA, 5S ribosomal pseudogene 393 Neighboring gene spectrin beta, non-erythrocytic 5 Neighboring gene microRNA 4310

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Cytosolic PLA2 genes possibly contribute to the etiology of schizophrenia. Tao R, et al. Am J Med Genet B Neuropsychiatr Genet, 2005 Aug 5. PMID 15999343
    2. Association analysis of two candidate phospholipase genes that map to the chromosome 15q15.1-15.3 region associated with reading disability. Morris DW, et al. Am J Med Genet B Neuropsychiatr Genet, 2004 Aug 15. PMID 15274049
    3. Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis. Degousee N, et al. J Biol Chem, 2002 Feb 15. PMID 11741884
    4. Molecular characterization of cytosolic phospholipase A2-beta. Song C, et al. J Biol Chem, 1999 Jun 11. PMID 10358058
    5. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. Ghosh M, et al. J Biol Chem, 2006 Jun 16. PMID 16617059

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. circulating human neutrophils express groups V and X sPLA(2) (GV and GX sPLA(2)) mRNA and contain GV and GX sPLA(2) proteins, whereas GIB, GIIA, GIID, GIIE, GIIF, GIII, and GXII sPLA(2)s are undetectable
      Title: Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor PubMed
    env HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    JMJD7-PLA2G4B protein
    Names
    jumonji domain containing 7-phospholipase A2, group IVB (cytosolic) read-through

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029927.1 RefSeqGene

      Range
      5001..25064
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001198588.2 → NP_001185517.1  JMJD7-PLA2G4B protein isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as cPLA2 beta2) lacks an alternate exon resulting in a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and shorter C-terminus, compared to isoform a.
      Source sequence(s)
      AC020659, BC013415, DA096882, DQ523799
      UniProtKB/Swiss-Prot
      P0C869
      Related
      ENSP00000342785.4, ENST00000342159.6
      Conserved Domains (3) summary
      cd04036
      Location:242 → 361
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam13621
      Location:38 → 223
      Cupin_8; Cupin-like domain
      cl11396
      Location:474 → 880
      Patatin_and_cPLA2; Patatins and Phospholipases

    2. NM_005090.4 → NP_005081.1  JMJD7-PLA2G4B protein isoform a

      See identical proteins and their annotated locations for NP_005081.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as cPLA2 beta) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF065215, BI768993, BU688449, DA080158, DA096882
      UniProtKB/Swiss-Prot
      P0C869
      Related
      ENSP00000371886.4, ENST00000382448.8
      Conserved Domains (3) summary
      cd07201
      Location:474 → 999
      cPLA2_Grp-IVB-IVD-IVE-IVF; Group IVB, IVD, IVE, and IVF cytosolic phospholipase A2; catalytic domain; Ca-dependent
      cd04036
      Location:242 → 361
      C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
      pfam13621
      Location:38 → 223
      Cupin_8; Cupin-like domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      41828092..41848143
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      39634005..39654098
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NR_015346.1: Suppressed sequence

      Description
      NR_015346.1: This RefSeq was permanently suppressed because it is incompletely processed.
    Nucleotide Protein
    Heading Accession and Version

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