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    DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B [ Homo sapiens (human) ]

    Gene ID: 9149, updated on 3-Apr-2024

    Summary

    Official Symbol
    DYRK1Bprovided by HGNC
    Official Full Name
    dual specificity tyrosine phosphorylation regulated kinase 1Bprovided by HGNC
    Primary source
    HGNC:HGNC:3092
    See related
    Ensembl:ENSG00000105204 MIM:604556; AllianceGenome:HGNC:3092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MIRK; AOMS3
    Summary
    This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
    Expression
    Broad expression in testis (RPKM 21.5), prostate (RPKM 4.7) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    19q13.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (39825350..39834162, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (42630272..42639084, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (40315990..40324802, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene leucine twenty homeobox Neighboring gene uncharacterized LOC124904719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40314468-40315454 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40315455-40316439 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10613 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10614 Neighboring gene microRNA 6719 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:40335824-40336564 Neighboring gene fibrillarin Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:40357069-40358268 Neighboring gene Fc gamma binding protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40376357-40376858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:40433231-40433732

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine/tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in myoblast fusion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptidyl-serine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    dual specificity tyrosine-phosphorylation-regulated kinase 1B
    Names
    dual specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
    minibrain-related kinase
    mirk protein kinase
    NP_004705.1
    NP_006474.1
    NP_006475.1
    XP_005259455.1
    XP_047295623.1
    XP_047295624.1
    XP_047295625.1
    XP_054178558.1
    XP_054178559.1
    XP_054178560.1
    XP_054178561.1
    XP_054187621.1
    XP_054187622.1
    XP_054187623.1
    XP_054187624.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034145.1 RefSeqGene

      Range
      5072..13884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004714.3NP_004705.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p69

      See identical proteins and their annotated locations for NP_004705.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as 'a') represents the longest transcript and encodes the longest isoform (p69, also known as isoform a).
      Source sequence(s)
      Y17999
      Consensus CDS
      CCDS12543.1
      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000312789.4, ENST00000323039.10
      Conserved Domains (1) summary
      cd14226
      Location:97436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    2. NM_006483.3NP_006474.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p65

      See identical proteins and their annotated locations for NP_006474.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as 'b') uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (p65, also known as isoform b) is shorter than isoform p69.
      Source sequence(s)
      BI964831, Y17999
      Consensus CDS
      CCDS46075.1
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000403182.1, ENST00000430012.6
      Conserved Domains (1) summary
      cd14226
      Location:97396
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
    3. NM_006484.3NP_006475.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform p66

      See identical proteins and their annotated locations for NP_006475.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3, also known as 'c') lacks an alternate in-frame segment in the 3' coding region, compared to variant 1. The encoded isoform (p66, also known as isoform c) is shorter than isoform p69.
      Source sequence(s)
      BI964831, Y17999
      Consensus CDS
      CCDS12544.1
      UniProtKB/TrEMBL
      B3KQI0
      Related
      ENSP00000221803.4, ENST00000348817.7
      Conserved Domains (1) summary
      cd14226
      Location:97408
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      39825350..39834162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439669.1XP_047295625.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

    2. XM_047439668.1XP_047295624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

    3. XM_047439667.1XP_047295623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7
      Related
      ENSP00000469863.2, ENST00000593685.5
    4. XM_005259398.5XP_005259455.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      See identical proteins and their annotated locations for XP_005259455.1

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463
      UniProtKB/TrEMBL
      B3KQI0
      Conserved Domains (1) summary
      cd14226
      Location:97436
      PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646206.1 Reference GRCh38.p14 PATCHES

      Range
      85226..94038 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331646.1XP_054187621.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7
    2. XM_054331647.1XP_054187622.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

    3. XM_054331648.1XP_054187623.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

    4. XM_054331649.1XP_054187624.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      42630272..42639084 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322583.1XP_054178558.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X1

      UniProtKB/TrEMBL
      A0A9H4CVU7
    2. XM_054322584.1XP_054178559.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X2

    3. XM_054322585.1XP_054178560.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X3

    4. XM_054322586.1XP_054178561.1  dual specificity tyrosine-phosphorylation-regulated kinase 1B isoform X4

      UniProtKB/Swiss-Prot
      O75258, O75788, O75789, Q9Y463