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    Zfp518b zinc finger protein 518B [ Mus musculus (house mouse) ]

    Gene ID: 100515, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Zfp518bprovided by MGI
    Official Full Name
    zinc finger protein 518Bprovided by MGI
    Primary source
    MGI:MGI:2140750
    See related
    Ensembl:ENSMUSG00000046572 AllianceGenome:MGI:2140750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf518b; 6820424L24Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within chromatin organization. Predicted to be active in nucleus. Orthologous to human ZNF518B (zinc finger protein 518B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 6.8), whole brain E14.5 (RPKM 6.7) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    5 B3; 5 20.77 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (38825828..38842120, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (38668484..38684984, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6325 Neighboring gene WD repeat domain 1 Neighboring gene predicted gene, 22249 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide D, pseudogene 2 Neighboring gene STARR-seq mESC enhancer starr_12921 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:39023837-39024020 Neighboring gene STARR-seq mESC enhancer starr_12923 Neighboring gene STARR-seq mESC enhancer starr_12924 Neighboring gene STARR-seq mESC enhancer starr_12927 Neighboring gene predicted gene, 22779 Neighboring gene cytokine-dependent hematopoietic cell linker Neighboring gene STARR-seq mESC enhancer starr_12931

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator. Maier VK, et al. Mol Cell Proteomics, 2015 Jun. PMID 25680957, Free PMC Article
    2. Activity-dependent neuroprotective protein recruits HP1 and CHD4 to control lineage-specifying genes. Ostapcuk V, et al. Nature, 2018 May. PMID 29795351
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator
      Title: Functional Proteomic Analysis of Repressive Histone Methyltransferase Complexes Reveals ZNF518B as a G9A Regulator.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 518B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081144.3 → NP_001074613.2  zinc finger protein 518B

      See identical proteins and their annotated locations for NP_001074613.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC093570
      Consensus CDS
      CCDS39078.2
      UniProtKB/Swiss-Prot
      B2RRE4, Q69ZC1
      UniProtKB/TrEMBL
      J3QPN0
      Related
      ENSMUSP00000061753.5, ENSMUST00000057258.11
      Conserved Domains (2) summary
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:167 → 189
      zf-H2C2_5; C2H2-type zinc-finger domain

    2. NM_001177902.2 → NP_001171373.1  zinc finger protein 518B

      See identical proteins and their annotated locations for NP_001171373.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-5 all encode the same protein.
      Source sequence(s)
      AC093570
      Consensus CDS
      CCDS39078.2
      UniProtKB/Swiss-Prot
      B2RRE4, Q69ZC1
      UniProtKB/TrEMBL
      J3QPN0
      Related
      ENSMUSP00000137381.2, ENSMUST00000179555.8
      Conserved Domains (2) summary
      sd00017
      Location:140 → 160
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13909
      Location:167 → 189
      zf-H2C2_5; C2H2-type zinc-finger domain

    3. NM_001408031.1 → NP_001394960.1  zinc finger protein 518B

      Status: VALIDATED

      Source sequence(s)
      AC093570
      UniProtKB/TrEMBL
      J3QPN0

    4. NM_001408032.1 → NP_001394961.1  zinc finger protein 518B

      Status: VALIDATED

      Source sequence(s)
      AC093570
      UniProtKB/TrEMBL
      J3QPN0

    5. NM_001408033.1 → NP_001394962.1  zinc finger protein 518B

      Status: VALIDATED

      Source sequence(s)
      AC093570
      UniProtKB/TrEMBL
      J3QPN0

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      38825828..38842120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B2RRE4.1 GenPept UniProtKB/Swiss-Prot:B2RRE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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