Il6st interleukin 6 signal transducer [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Il6stprovided by MGI
Official Full Name: interleukin 6 signal transducerprovided by MGI
Primary source: MGI:MGI:96560
See related: Ensembl:ENSMUSG00000021756 AllianceGenome:MGI:96560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CD130; gp130; D13Ertd699e; 5133400A03Rik
Summary: Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway. Acts upstream of or within several processes, including glycogen metabolic process; positive regulation of astrocyte differentiation; and regulation of Notch signaling pathway. Located in dendrite; external side of plasma membrane; and neuronal cell body. Is expressed in several structures, including alimentary system; brain; early conceptus; immune system; and reproductive system. Used to study rheumatoid arthritis and stomach cancer. Human ortholog(s) of this gene implicated in arteriosclerosis; hyper IgE recurrent infection syndrome 4; and hyperandrogenism. Orthologous to human IL6ST (interleukin 6 cytokine family signal transducer). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in bladder adult (RPKM 57.5), subcutaneous fat pad adult (RPKM 32.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 D2.2; 13 63.73 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (112600604..112643394)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (112464070..112506860)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gp130-HIF1alpha axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Title: Gp130-HIF1α axis-induced vascular damage is prevented by the short-term inhibition of IL-6 receptor signaling.
Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.
Title: Cell-Autonomous Constitutive gp130 Signaling in T Cells Amplifies TH17 Cell Responses and Causes Severe Lung Inflammation.
Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Title: Constitutive Activation of gp130 in T Cells Results in Senescence and Premature Aging.
Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis.
Title: Gp130 Promotes Inflammation via the STAT3/JAK2 Pathway in Allergic Conjunctivitis.
Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway.
Title: Inhibition of gp130 alleviates LPS-induced lung injury by attenuating apoptosis and inflammation through JAK1/STAT3 signaling pathway.
Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.
Title: Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.
Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
Title: Cytokine receptor gp130 promotes postnatal proliferation of cardiomyocytes required for the normal functional development of the heart.
Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain.
Title: Genetic and functional evidence for gp130/IL6ST-induced transient receptor potential ankyrin 1 upregulation in uninjured but not injured neurons in a mouse model of neuropathic pain.
Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.
Title: Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling.
gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.
Title: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes.

Submit: New GeneRIF Correction See all GeneRIFs (123)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (14) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237111

NoName (e-PCR)
- UniSTS:237112

M83336 (e-PCR)
- UniSTS:124989

Il6st (e-PCR), detects polymorphism
- UniSTS:259184

X62646 (e-PCR)
- UniSTS:180600

AU015818 (e-PCR)
- UniSTS:167123

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor activity	ISO Inferred from Sequence Orthology more info
enables ciliary neurotrophic factor receptor binding	ISO Inferred from Sequence Orthology more info
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to growth factor binding	ISO Inferred from Sequence Orthology more info
enables growth factor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-11 binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-11 receptor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to interleukin-6 binding	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-6 binding	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-6 receptor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to interleukin-6 receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to interleukin-6 receptor binding	ISO Inferred from Sequence Orthology more info
contributes_to leukemia inhibitory factor receptor activity	ISO Inferred from Sequence Orthology more info
contributes_to oncostatin-M receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in ciliary neurotrophic factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within glycogen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-27-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intestinal epithelial cell development	IDA Inferred from Direct Assay more info	PubMed
involved_in intestinal epithelial cell development	ISO Inferred from Sequence Orthology more info
involved_in leukemia inhibitory factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oncostatin-M-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in triglyceride mobilization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
part_of ciliary neurotrophic factor receptor complex	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
part_of interleukin-6 receptor complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body membrane	ISO Inferred from Sequence Orthology more info
part_of oncostatin-M receptor complex	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-6 receptor subunit beta

Names: IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; membrane glycoprotein 130; oncostatin-M receptor subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010560.3 → NP_034690.3 interleukin-6 receptor subunit beta precursor

See identical proteins and their annotated locations for NP_034690.3

Status: VALIDATED

Source sequence(s)

BC058679, BU709006, CJ177012, CV556562

Consensus CDS

CCDS26773.1

UniProtKB/Swiss-Prot

G5E8D2, Q00560

UniProtKB/TrEMBL

H6WCS3, Q6PDI9

Related

ENSMUSP00000138836.2, ENSMUST00000183663.8

Conserved Domains (4) summary

smart00060
Location:521 → 597

FN3; Fibronectin type 3 domain

cd00063
Location:220 → 319

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:125 → 213

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

112600604..112643394

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157858.1 → XP_036013751.1 interleukin-6 receptor subunit beta isoform X1

UniProtKB/Swiss-Prot

G5E8D2, Q00560

UniProtKB/TrEMBL

H6WCS3, Q6PDI9

Conserved Domains (4) summary

smart00060
Location:521 → 597

FN3; Fibronectin type 3 domain

cd00063
Location:220 → 319

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam06328
Location:26 → 112

Lep_receptor_Ig; Ig-like C2-type domain

cl21522
Location:125 → 213

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...