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    Hivep3 human immunodeficiency virus type I enhancer binding protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 16656, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Hivep3provided by MGI
    Official Full Name
    human immunodeficiency virus type I enhancer binding protein 3provided by MGI
    Primary source
    MGI:MGI:106589
    See related
    Ensembl:ENSMUSG00000028634 AllianceGenome:MGI:106589
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rc; Krc; KBP1; Shn3; Zas3; KBP-1; A130075N07; Schnurri-3; 2900056N03Rik; E030045D18Rik
    Summary
    Enables DNA binding activity. Acts upstream of or within skeletal muscle cell differentiation. Located in nucleus. Is expressed in bone; brain; ganglia; genitourinary system; and hemolymphoid system. Orthologous to human HIVEP3 (HIVEP zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in thymus adult (RPKM 3.7), cortex adult (RPKM 2.0) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hivep3 in Genome Data Viewer
    Location:
    4 D2.1; 4 55.51 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119590982..119992608)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119733759..120138045)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:119342138-119342339 Neighboring gene predicted gene, 35761 Neighboring gene STARR-positive B cell enhancer ABC_E1653 Neighboring gene predicted gene, 35957 Neighboring gene STARR-positive B cell enhancer ABC_E11252 Neighboring gene STARR-positive B cell enhancer ABC_E4655 Neighboring gene STARR-positive B cell enhancer ABC_E9594 Neighboring gene STARR-seq mESC enhancer starr_11240 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:119569908-119570109 Neighboring gene STARR-positive B cell enhancer mm9_chr4:119631902-119632203 Neighboring gene STARR-positive B cell enhancer ABC_E522 Neighboring gene predicted gene, 38632 Neighboring gene predicted gene, 36215 Neighboring gene STARR-seq mESC enhancer starr_11242 Neighboring gene predicted gene, 36134 Neighboring gene predicted gene, 36073 Neighboring gene endothelin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis. Stavre Z, et al. Proc Natl Acad Sci U S A, 2023 May 9. PMID 37141171, Free PMC Article
    2. Thymic iNKT single cell analyses unmask the common developmental program of mouse innate T cells. Harsha Krovi S, et al. Nat Commun, 2020 Dec 7. PMID 33288744, Free PMC Article
    3. Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development. Allen CE, et al. Gene Expr, 2007. PMID 18257392, Free PMC Article
    4. Schnurri-3: a key regulator of postnatal skeletal remodeling. Jones DC, et al. Adv Exp Med Biol, 2007. PMID 17966382
    5. KRC transcripts: identification of an unusual alternative splicing event. Mak CH, et al. Immunogenetics, 1998 Jun. PMID 9601941

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
      Title: Schnurri-3 drives tumor growth and invasion in cancer cells expressing interleukin-13 receptor alpha 2.
    2. Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
      Title: Schnurri-3 inhibition suppresses bone and joint damage in models of rheumatoid arthritis.
    3. Thus, Alg2, as a downstream mediator of Hivep3, suppresses osteogenesis, whereas it promotes chondrogenesis.
      Title: Human immunodeficiency virus type 1 enhancer-binding protein 3 is essential for the expression of asparagine-linked glycosylation 2 in the regulation of osteoblast and chondrocyte differentiation.
    4. Knockdown of Shn3 in adult mice results in a high-bone mass phenotype.
      Title: Schnurri-3 regulates ERK downstream of WNT signaling in osteoblasts.
    5. Shn3 expression in mesenchymal cells directly controls osteoblastic bone formation and indirectly regulates osteoclastic bone resorption.
      Title: Control of bone resorption in mice by Schnurri-3.
    6. ZAS3 was a crucial molecule in osteoclast differentiation.
      Title: The large zinc finger protein ZAS3 is a critical modulator of osteoclastogenesis.
    7. report that mice bearing parallel null mutations in the adapter proteins Schnurri2 (Shn2) and Schnurri3 (Shn3) exhibit defects in patterning of the axial skeleton during embryogenesis.
      Title: Uncoupling of growth plate maturation and bone formation in mice lacking both Schnurri-2 and Schnurri-3.
    8. Gel mobility shift assays showed altered DNA binding activities of NF-kappaB and AP-1 proteins in ZAS3-deficient tissues, including the thymus. Lymphocyte analysis suggested a subtle function of ZAS3 in regulating T-cell development and activation
      Title: Disruption of ZAS3 in mice alters NF-kappaB and AP-1 DNA binding and T-cell development.
    9. study reveals an essential role for Shn3 as a regulator of postnatal bone mass
      Title: Schnurri-3: a key regulator of postnatal skeletal remodeling.
    10. results show Schnurri-3 (Shn3) is an essential regulator of adult bone formation; Shn3 was found to control levels of Runx2, by promoting its degradation through recruitment of WWP1 to Runx2
      Title: Regulation of adult bone mass by the zinc finger adapter protein Schnurri-3.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (5)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within skeletal muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor HIVEP3
    Names
    KB-binding and recognition component
    KB-binding and regognition component
    human immunodeficiency virus type I enhancer-binding protein 3 homolog
    kappa B and Rss recognition component
    kappa-B and V(D)J recombination signal sequences-binding protein
    kappa-binding protein 1
    recombinant component
    zinc finger protein ZAS3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010657.3 → NP_034787.2  transcription factor HIVEP3

      See identical proteins and their annotated locations for NP_034787.2

      Status: VALIDATED

      Source sequence(s)
      AL606916, AL606930, AL607142
      Consensus CDS
      CCDS38863.1
      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Related
      ENSMUSP00000101914.3, ENSMUST00000106307.9
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      119590982..119992608
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502817.4 → XP_006502880.1  transcription factor HIVEP3 isoform X1

      See identical proteins and their annotated locations for XP_006502880.1

      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    2. XM_036163749.1 → XP_036019642.1  transcription factor HIVEP3 isoform X1

      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    3. XM_011240452.3 → XP_011238754.1  transcription factor HIVEP3 isoform X1

      See identical proteins and their annotated locations for XP_011238754.1

      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    4. XM_006502815.4 → XP_006502878.1  transcription factor HIVEP3 isoform X1

      See identical proteins and their annotated locations for XP_006502878.1

      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    5. XM_011240453.3 → XP_011238755.1  transcription factor HIVEP3 isoform X1

      See identical proteins and their annotated locations for XP_011238755.1

      UniProtKB/Swiss-Prot
      A2A884, A2MZW0, Q69ZG6, Q6SNP9
      Related
      ENSMUSP00000130249.3, ENSMUST00000166542.3
      Conserved Domains (6) summary
      smart00451
      Location:1745 → 1778
      ZnF_U1; U1-like zinc finger
      PHA03247
      Location:1845 → 2315
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:187 → 207
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:1722 → 1742
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1720 → 1742
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:200 → 224
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. XR_867814.3 RNA Sequence

    2. XR_003954883.2 RNA Sequence

    3. XR_001784097.2 RNA Sequence

    4. XR_003954884.2 RNA Sequence

    5. XR_004941818.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A2A884.1 GenPept UniProtKB/Swiss-Prot:A2A884

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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